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Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging

1
Department of Biology and Biotechnology “L. Spallanzani”, University of Pavia, 27100 Pavia, Italy
2
Centro Grandi Strumenti, University of Pavia, 27100 Pavia, Italy
3
Laboratory of Clinical & Experimental Toxicology, Pavia Poison Centre, National Toxicology Information Centre, Toxicology Unit, ICS Maugeri SpA, IRCCS Pavia, 27100 Pavia, Italy
4
Department of Earth and Environmental Sciences, University of Pavia, 27100 Pavia, Italy
5
Research Institute of Green Science and Technology, Shizuoka University, Shizuoka 422-8529, Japan
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(4), 715; https://doi.org/10.3390/nu11040715
Received: 7 March 2019 / Revised: 19 March 2019 / Accepted: 25 March 2019 / Published: 27 March 2019
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Abstract

Frailty is a geriatric syndrome associated with both locomotor and cognitive decline, implicated in both poor quality of life and negative health outcomes. One central question surrounding frailty is whether phenotypic frailty is associated with the cognitive impairment during aging. Using spontaneous behavioral tests and by studying the dynamic change during aging, we demonstrated that the two form of vulnerability, locomotor and recognition memory decline, develop in parallel and therefore, integration of the motoric and cognitive evaluations are imperative. We developed an integrated frailty index based on both phenotypic and recognition memory performances. Hericium erinaceus (H. erinaceus) is a medicinal mushroom that improves recognition memory in mice. By using HPLC-UV-ESI/MS analyses we obtained standardized amounts of erinacine A and hericenones C and D in H. erinaceus extracts, that were tested in our animal model of physiological aging. Two-month oral supplementation with H. erinaceus reversed the age-decline of recognition memory. Proliferating cell nuclear antigen (PCNA) and doublecortin (DCX) immunohistochemistry in the hippocampus and cerebellum in treated mice supported a positive effect of an H. erinaceus on neurogenesis in frail mice. View Full-Text
Keywords: aging; phenotypic frailty; cognitive decline; Hericium erinaceus; erinacines; hericenones; medicinal mushrooms supplementation; neurogenesis aging; phenotypic frailty; cognitive decline; Hericium erinaceus; erinacines; hericenones; medicinal mushrooms supplementation; neurogenesis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Ratto, D.; Corana, F.; Mannucci, B.; Priori, E.C.; Cobelli, F.; Roda, E.; Ferrari, B.; Occhinegro, A.; Di Iorio, C.; De Luca, F.; Cesaroni, V.; Girometta, C.; Bottone, M.G.; Savino, E.; Kawagishi, H.; Rossi, P. Hericium erinaceus Improves Recognition Memory and Induces Hippocampal and Cerebellar Neurogenesis in Frail Mice during Aging. Nutrients 2019, 11, 715.

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