Next Article in Journal
The Impact of Aerobic Exercise and Badminton on HDL Cholesterol Levels in Adult Taiwanese
Next Article in Special Issue
Intestinal Anti-Inflammatory Effect of a Peptide Derived from Gastrointestinal Digestion of Buffalo (Bubalus bubalis) Mozzarella Cheese
Previous Article in Journal
Insulin Controls Triacylglycerol Synthesis through Control of Glycerol Metabolism and Despite Increased Lipogenesis
Previous Article in Special Issue
Exclusive Enteral Nutrition: Clinical Effects and Changes in Mucosal Cytokine Profile in Pediatric New Inflammatory Bowel Disease
Article Menu

Export Article

Open AccessArticle
Nutrients 2019, 11(3), 514;

Dietary Protein Intake Level Modulates Mucosal Healing and Mucosa-Adherent Microbiota in Mouse Model of Colitis

UMR PNCA, AgroParisTech, INRA, Université Paris-Saclay, 75005 Paris, France
UMR MICALIS, AgroParisTech, INRA, Université Paris-Saclay, 78350 Jouy-en-Josas, France
H2P2, Biosit-Biogenouest, Université de Rennes 1, 35005 Rennes, France
Author to whom correspondence should be addressed.
Received: 11 February 2019 / Revised: 22 February 2019 / Accepted: 24 February 2019 / Published: 28 February 2019
(This article belongs to the Special Issue Nutrition in Inflammatory Bowel Disease (IBD))
Full-Text   |   PDF [1904 KB, uploaded 28 February 2019]   |  
  |   Review Reports


Mucosal healing after an inflammatory flare is associated with lasting clinical remission. The aim of the present work was to evaluate the impact of the amount of dietary protein on epithelial repair after an acute inflammatory episode. C57BL/6 DSS-treated mice received isocaloric diets with different levels of dietary protein: 14% (P14), 30% (P30) and 53% (P53) for 3 (day 10), 6 (day 13) and 21 (day 28) days after the time of colitis maximal intensity. While the P53 diet worsened the DSS- induced inflammation both in intensity and duration, the P30 diet, when compared to the P14 diet, showed a beneficial effect during the epithelial repair process by accelerating inflammation resolution, reducing colonic permeability and increasing epithelial repair together with epithelial hyperproliferation. Dietary protein intake also impacted mucosa-adherent microbiota composition after inflammation since P30 fed mice showed increased colonization of butyrate-producing genera throughout the resolution phase. This study revealed that in our colitis model, the amount of protein in the diet modulated mucosal healing, with beneficial effects of a moderately high-protein diet, while very high-protein diet displayed deleterious effects on this process. View Full-Text
Keywords: dietary protein level; colitis; epithelial repair; mucosa-adherent microbiota dietary protein level; colitis; epithelial repair; mucosa-adherent microbiota

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Vidal-Lletjós, S.; Andriamihaja, M.; Blais, A.; Grauso, M.; Lepage, P.; Davila, A.-M.; Viel, R.; Gaudichon, C.; Leclerc, M.; Blachier, F.; Lan, A. Dietary Protein Intake Level Modulates Mucosal Healing and Mucosa-Adherent Microbiota in Mouse Model of Colitis. Nutrients 2019, 11, 514.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top