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Nutrients 2019, 11(2), 272;

UP1306: A Composition Containing Standardized Extracts of Acacia catechu and Morus alba for Arthritis Management

Unigen Inc., 2121 South State Street, Suite 400, Tacoma, WA 98405, USA
Fred Hutch Cancer Research, 1100 Fairview Ave N, Seattle, WA 98109, USA
Author to whom correspondence should be addressed.
Received: 20 December 2018 / Revised: 23 January 2019 / Accepted: 23 January 2019 / Published: 26 January 2019
PDF [3844 KB, uploaded 26 January 2019]


Osteoarthritis (OA) is characterized by progressive articular cartilage degradation. Although there have been significant advances in OA management, to date, there are no effective treatment options to modify progression of the disease. We believe these unmet needs could be bridged by nutrients from natural products. Collagen induced arthritis in rats was developed and utilized to evaluate anti-inflammatory and cartilage protection activity of orally administered botanical composition, UP1306 (50 mg/kg) and Methotrexate (75 µg/kg) daily for three weeks. Objective arthritis severity markers, urine, synovial lavage, and serum were collected. At necropsy, the hock joint from each rat was collected for histopathology analysis. Urinary cartilage degradation marker (CTX-II), pro-inflammatory cytokines (tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and IL-6), and proteases (Matrix Metallopeptidase 3 (MMP3) and 13) were measured. Rats treated with UP1306 showed statistically significant improvements in arthritis severity markers, including uCTX-II (91.4% vs. collagen-induced arthritis (CIA)), serum IL-1β, TNF-α, and IL-6 levels as well as synovial MMP-13. The histopathology data were also well aligned with the severity score of arthritis for both UP1306 and Methotrexate. UP1306, a botanical composition that contains a standardized blend of extracts from the heartwood of Acacia catechu and the root bark of Morus alba, could potentially be considered as a dietary supplement product for the management of arthritis. View Full-Text
Keywords: collagen induced arthritis; Acacia catechu; Morus alba; UP1306 collagen induced arthritis; Acacia catechu; Morus alba; UP1306

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Yimam, M.; Horm, T.; Wright, L.; Jiao, P.; Hong, M.; Brownell, L.; Jia, Q. UP1306: A Composition Containing Standardized Extracts of Acacia catechu and Morus alba for Arthritis Management. Nutrients 2019, 11, 272.

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