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Precision Nutrition and Cancer Relapse Prevention: A Systematic Literature Review

1
Institute for Cancer Genetics, Columbia University Medical Center, New York, NY 10032, USA
2
IMDEA Food Institute, 28049 Madrid, Spain
3
Institute of Food Science Research (CIAL), Autónoma de Madrid University, 28049 Madrid, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(11), 2799; https://doi.org/10.3390/nu11112799
Received: 18 October 2019 / Revised: 9 November 2019 / Accepted: 14 November 2019 / Published: 16 November 2019
Cancer mortality rates are undergoing a global downward trend; however, metastasis and relapse after surgery and adjuvant treatments still correlate with poor prognosis and represent the most significant challenges in the treatment of this disease. Advances in genomics, metabolomics, and proteomics are improving our understanding regarding cancer metabolic diversity, resulting in detailed classifications of tumors and raising the effectiveness of precision medicine. Likewise, the growing knowledge of interactions between nutrients and the expression of certain genes could lead to cancer therapies based on precision nutrition strategies. This review aims to identify the recent advances in the knowledge of the mechanistic role of bioactive phytochemicals in foodstuffs in tumor progression, metastasis, and chemo-resistance in order to assess their potential use in precision nutrition therapies targeting relapse in lung, breast, colon, and prostate cancer, and leukemia. A considerable number of bioactive phytochemicals in foodstuffs were identified in the literature with proven effects modulating tumor growth, progression, and metastasis. In addition, the use of foodstuffs in cancer, and specifically in relapse therapies, is being reinforced by the development of different formulations that significantly increase the therapeutic efficiency of these products. This can open the possibility for testing combinations of bioactive phytochemicals with cancer relapse treatments as a potential prevention strategy. View Full-Text
Keywords: precision nutrition; cancer relapse; bioactive phytochemical foodstuffs; lung; breast; prostate; colon; leukemia precision nutrition; cancer relapse; bioactive phytochemical foodstuffs; lung; breast; prostate; colon; leukemia
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Reglero, C.; Reglero, G. Precision Nutrition and Cancer Relapse Prevention: A Systematic Literature Review. Nutrients 2019, 11, 2799.

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