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Review

Systematic Review with Meta-Analysis: Lactobacillus reuteri DSM 17938 for Treating Acute Gastroenteritis in Children. An Update

Department of Paediatrics, The Medical University of Warsaw, 02-091 Warsaw, Poland
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Nutrients 2019, 11(11), 2762; https://doi.org/10.3390/nu11112762
Received: 23 October 2019 / Revised: 8 November 2019 / Accepted: 11 November 2019 / Published: 14 November 2019
The effectiveness of Lactobacillus reuteri DSM 17938 (L. reuteri) for the management of acute gastroenteritis (AGE) has been recently questioned. We performed a systematic review to update evidence on L. reuteri for treating AGE in children. We searched MEDLINE, EMBASE, the Cochrane Library databases, and additional data sources from January 2016 (end of search for our 2016 systematic review) to August 2019. The primary outcomes were stool volume and duration of diarrhea. Four RCTs were included. None of them evaluated stool volume. Compared with placebo or no treatment, L. reuteri reduced diarrhea duration (four RCTs, n = 347, mean difference, MD −0.87 days, 95% CI [−1.43, −0.31]). L. reuteri use was also associated with a reduced duration of hospitalization (three RCTs, n = 284, MD −0.54 days, 95% CI [−1.09, 0.0]). The small effect sizes of limited clinical relevance and methodological limitations of the included trials should be noted when interpreting these findings. View Full-Text
Keywords: systematic review; probiotics; microbiota; diarrhea; infants; children systematic review; probiotics; microbiota; diarrhea; infants; children
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MDPI and ACS Style

Patro-Gołąb, B.; Szajewska, H. Systematic Review with Meta-Analysis: Lactobacillus reuteri DSM 17938 for Treating Acute Gastroenteritis in Children. An Update. Nutrients 2019, 11, 2762. https://doi.org/10.3390/nu11112762

AMA Style

Patro-Gołąb B, Szajewska H. Systematic Review with Meta-Analysis: Lactobacillus reuteri DSM 17938 for Treating Acute Gastroenteritis in Children. An Update. Nutrients. 2019; 11(11):2762. https://doi.org/10.3390/nu11112762

Chicago/Turabian Style

Patro-Gołąb, Bernadeta, and Hania Szajewska. 2019. "Systematic Review with Meta-Analysis: Lactobacillus reuteri DSM 17938 for Treating Acute Gastroenteritis in Children. An Update" Nutrients 11, no. 11: 2762. https://doi.org/10.3390/nu11112762

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