Effects of Flaxseed and Its Components on Mammary Gland MiRNome: Identification of Potential Biomarkers to Prevent Breast Cancer Development
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animal Study and Dietary Treatments
2.2. Serum Lignan Analysis
2.3. NanoString nCounter miRNA Profiling and Data Analysis
2.4. MiRNAs Target Prediction and Pathway Analysis
2.5. Statistical Analysis
3. Results
3.1. Body Weights and Food Intake
3.2. Serum Lignan Concentration
3.3. Mammary Gland miRNome
3.4. Identification of Gene Targets of Deregulated miRNAs and Pathway Enrichment Analysis
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Taibi, A.; Lin, Z.; Tsao, R.; Thompson, L.U.; Comelli, E.M. Effects of Flaxseed and Its Components on Mammary Gland MiRNome: Identification of Potential Biomarkers to Prevent Breast Cancer Development. Nutrients 2019, 11, 2656. https://doi.org/10.3390/nu11112656
Taibi A, Lin Z, Tsao R, Thompson LU, Comelli EM. Effects of Flaxseed and Its Components on Mammary Gland MiRNome: Identification of Potential Biomarkers to Prevent Breast Cancer Development. Nutrients. 2019; 11(11):2656. https://doi.org/10.3390/nu11112656
Chicago/Turabian StyleTaibi, Amel, Zhen Lin, Rong Tsao, Lilian U. Thompson, and Elena M. Comelli. 2019. "Effects of Flaxseed and Its Components on Mammary Gland MiRNome: Identification of Potential Biomarkers to Prevent Breast Cancer Development" Nutrients 11, no. 11: 2656. https://doi.org/10.3390/nu11112656