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Open AccessArticle

Sex-Specific Glucose Homeostasis and Anthropometric Responses to Sleeve Gastrectomy in Obese Patients

1
School of Medicine, University of California, San Francisco 505 Parnassus Ave, San Francisco, CA 94143, USA
2
Department of Endocrinology, Diabetology and Internal Medicine, Medical University of Bialystok, Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland
3
Clinical Research Centre, Medical University of Bialystok, Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland
4
1st Clinical Department of General and Endocrine Surgery, Medical University of Bialystok, Sklodowskiej-Curie 24A, 15-276 Bialystok, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(10), 2408; https://doi.org/10.3390/nu11102408
Received: 1 August 2019 / Revised: 12 September 2019 / Accepted: 19 September 2019 / Published: 9 October 2019
Bariatric surgery rapidly and effectively treats obesity and its comorbidities like dysregulated glucose homeostasis. Despite the sex-balanced incidence of obesity in most human populations, women have sought this intervention more frequently than men. However, as the number of bariatric surgeries rapidly rises, it is increasingly urgent to understand how sex-specific differences may emerge in metabolic and anthropometric parameters. Hundred fifty-four obese patients (47% men and 53% women) from the Bialystok Bariatric Surgery Study underwent sleeve gastrectomy and were measured for 25 parameters at baseline (immediately prior to surgery) and at four follow-up visits over one year. We used generalized linear mixed models to detect sex-specific differences in the time series of responses parameters. Unlike most previous studies with older cross-sections of men than women, our cohort was age-matched, and men were less healthy at baseline. Of parameters that showed a significant cohort-wide (across-sex) response, 14 (56%) also showed sex-specific responses with men improving more than women. In particular, men remitted in diabetes symptoms more strongly, rapidly, and durably than women. Taken together, our results indicate that men may benefit more from sleeve gastrectomy and that this difference in improvement may be related to more progressed morbidity prior to surgery independent of age. View Full-Text
Keywords: bariatric surgery; diabetes; gender; glucose homeostasis; sex; sleeve gastrectomy bariatric surgery; diabetes; gender; glucose homeostasis; sex; sleeve gastrectomy
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Taylor, M.A.; Szczerbinski, L.; Citko, A.; Niemira, M.; Gorska, M.; Hady, H.R.; Kretowski, A. Sex-Specific Glucose Homeostasis and Anthropometric Responses to Sleeve Gastrectomy in Obese Patients. Nutrients 2019, 11, 2408.

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