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β-Eudesmol, an Oxygenized Sesquiterpene, Reduces the Increase in Saliva 3-Methoxy-4-Hydroxyphenylglycol After the “Trier Social Stress Test” in Healthy Humans: A Randomized, Double-Blind, Placebo-Controlled Cross-Over Study

1
Research Laboratories for Health Science and Food Technologies, Kirin Company, Ltd., 1-13-5, Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan
2
Cognitive and Molecular Research Institute of Brain Diseases, Kurume University, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japan
3
Department of Human Studies, Beppu University, Beppu, Oita 874-8501, Japan
4
Department of Psychology, Kurume University, 1635 Mii-machi, Kurume, Fukuoka 839-8502, Japan
*
Author to whom correspondence should be addressed.
Present address: Central Laboratories for Key Technologies, Kirin Company, Ltd., 1-13-5, Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.
Nutrients 2019, 11(1), 9; https://doi.org/10.3390/nu11010009
Received: 15 November 2018 / Revised: 15 December 2018 / Accepted: 19 December 2018 / Published: 20 December 2018
Hops, the immature inflorescences of the female hop plant (Humulus lupulus L.) are one of the main components of beer and provides flavor and bitterness. β-Eudesmol, an oxygenated sesquiterpene, is reported to accumulate in a particular hop cultivar. Recently, we revealed that β-Eudesmol ingestion affected autonomic nerve activity in an animal model. The effect on humans has not been elucidated, therefore, we investigated the effects of β-Eudesmol on reducing objective and subjective markers related to sympathetic nerve activity after the application of mental stress in healthy participants. Fifty participants (male and female aged 20 to 50 years) were randomly assigned to two groups. Five minutes before taking the Trier Social Stress Test (TSST) as a mental stressor, participants in each group ingested a beverage containing β-Eudesmol, the active beverage, or a placebo beverage that did not contain β-Eudesmol. Saliva 3-methoxy-4-hydroxyphenylglycol (MHPG), a major product of noradrenaline breakdown and a representative marker of sympathetic nerve activity, was significantly lower just after the TSST in the active group compared with the placebo group. Saliva cortisol, a marker of the endocrine stress response system, was not significantly different between the two groups. No adverse events related to test beverage ingestion were observed. This is the first experimental evidence of β-Eudesmol effect for mental stress in human. View Full-Text
Keywords: β-Eudesmol; mental stress; saliva 3-methoxy-4-hydroxyphenylglycol; Trier Social Stress Test (TSST) β-Eudesmol; mental stress; saliva 3-methoxy-4-hydroxyphenylglycol; Trier Social Stress Test (TSST)
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Ohara, K.; Misaizu, A.; Kaneko, Y.; Fukuda, T.; Miyake, M.; Miura, Y.; Okamura, H.; Yajima, J.; Tsuda, A. β-Eudesmol, an Oxygenized Sesquiterpene, Reduces the Increase in Saliva 3-Methoxy-4-Hydroxyphenylglycol After the “Trier Social Stress Test” in Healthy Humans: A Randomized, Double-Blind, Placebo-Controlled Cross-Over Study. Nutrients 2019, 11, 9.

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