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The Effects of Oral Magnesium Supplementation on Glycemic Response among Type 2 Diabetes Patients

Department of Clinical Nutrition, Faculty of Applied Medical Sciences, Al-Azhar University-Gaza, Jamal Abdl Naser St., P.O. Box 1277, Gaza, Gaza Strip 00970, Palestine
Author to whom correspondence should be addressed.
Nutrients 2019, 11(1), 44;
Received: 4 September 2018 / Revised: 25 September 2018 / Accepted: 29 October 2018 / Published: 26 December 2018
PDF [228 KB, uploaded 26 December 2018]


Background: Magnesium (Mg) supplementation may help control glycemic response among type 2 diabetes (T2D) patients. Objective: This study means to determine whether Mg supplementation improves glycemic control indicators in patients with T2D. Methods: After one week of the dietary stabilization phase, 42 T2D patients were stratified according to sex, age, fasting blood sugar (FBS) and Mg levels and then randomly allocated into two groups. The intervention group was on 250 mg/day of elemental Mg for three months while the control group did not receive any type of supplements throughout the intervention period. Results: The daily administration of 250 mg of elemental Mg indicated a significant improvement in HbA1C (8.32 to 7.96%, p < 0.001), insulin levels (IL) (15.56 to 12.18 μIU/mL, p < 0.001), C-peptide (2.28 to 1.90 ng/mL, p = 0.001), HOMA.IR (6.16 to 4.44, p < 0.001) and HOMA.β% (59.99 to 52.37, p = 0.036) of the intervention group when compared with the control group after three months of intervention. Conclusion: The results of this study revealed that oral Mg supplementation reduces insulin resistance and improves the glycemic control indicators among T2D patients. Trial registration: current controlled trials PHRC/HC/32/15. Registered 5 October 2015. View Full-Text
Keywords: diabetes mellitus; magnesium; blood glucose; insulin diabetes mellitus; magnesium; blood glucose; insulin
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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ELDerawi, W.A.; Naser, I.A.; Taleb, M.H.; Abutair, A.S. The Effects of Oral Magnesium Supplementation on Glycemic Response among Type 2 Diabetes Patients. Nutrients 2019, 11, 44.

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