Next Article in Journal
Dietary Factors Associated with Frailty in Old Adults: A Review of Nutritional Interventions to Prevent Frailty Development
Previous Article in Journal
Orthorexic Tendency in Polish Students: Exploring Association with Dietary Patterns, Body Satisfaction and Weight
Article

Multivitamin and Mineral Supplementation Containing Phytonutrients Scavenges Reactive Oxygen Species in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Trial

1
Department of Nutritional Science and Food Management, Ewha Womans Universiy, Seoul 03760, Korea
2
Department of Systems Biotechnology, Konkuk University, Seoul 05029, Korea
3
Department of Bioscience and Biotechnology, Konkuk University, Seoul 05029, Korea
4
Department of Food and Nutrition, Hannam University, Daejeon 34430, Korea
5
Access Business Group International, LLC, 5600 Beach Blvd., Buena Park, CA 90621, USA
6
Department of Food Science and Technology, Seoul National University of Science and Technology, Seoul 01811, Korea
*
Authors to whom correspondence should be addressed.
Nutrients 2019, 11(1), 101; https://doi.org/10.3390/nu11010101
Received: 4 December 2018 / Revised: 26 December 2018 / Accepted: 29 December 2018 / Published: 5 January 2019
Phytonutrients and vitamin and mineral supplementation have been reported to provide increased antioxidant capacity in humans; however, there is still controversy. In the current clinical trial, we examined the antioxidant and DNA protection capacity of a plant-based, multi-vitamin/mineral, and phytonutrient (PMP) supplementation in healthy adults who were habitually low in the consumption of fruits and vegetables. This study was an eight-week, double-blind, randomized, parallel-arm, and placebo-controlled trial. PMP supplementation for eight weeks reduced reactive oxygen species (ROS) and prevented DNA damage without altering endogenous antioxidant system. Plasma vitamins and phytonutrients were significantly correlated with ROS scavenging and DNA damage. In addition, gene expression analysis in PBMC showed subtle changes in superoxide metabolic processes. In this study, we showed that supplementation with a PMP significantly improved ROS scavenging activity and prevented DNA damage. However, additional research is still needed to further identify mechanisms of actions and the role of circulating phytonutrient metabolites. View Full-Text
Keywords: phytonutrients; ROS scavenging; DNA damage; antioxidant capacity; human clinical study phytonutrients; ROS scavenging; DNA damage; antioxidant capacity; human clinical study
Show Figures

Figure 1

MDPI and ACS Style

Kang, S.; Lim, Y.; Kim, Y.J.; Jung, E.S.; Suh, D.H.; Lee, C.H.; Park, E.; Hong, J.; Velliquette, R.A.; Kwon, O.; Kim, J.Y. Multivitamin and Mineral Supplementation Containing Phytonutrients Scavenges Reactive Oxygen Species in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Trial. Nutrients 2019, 11, 101. https://doi.org/10.3390/nu11010101

AMA Style

Kang S, Lim Y, Kim YJ, Jung ES, Suh DH, Lee CH, Park E, Hong J, Velliquette RA, Kwon O, Kim JY. Multivitamin and Mineral Supplementation Containing Phytonutrients Scavenges Reactive Oxygen Species in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Trial. Nutrients. 2019; 11(1):101. https://doi.org/10.3390/nu11010101

Chicago/Turabian Style

Kang, Seunghee, Yeni Lim, You J. Kim, Eun S. Jung, Dong H. Suh, Choong H. Lee, Eunmi Park, Jina Hong, Rodney A. Velliquette, Oran Kwon, and Ji Y. Kim 2019. "Multivitamin and Mineral Supplementation Containing Phytonutrients Scavenges Reactive Oxygen Species in Healthy Subjects: A Randomized, Double-Blinded, Placebo-Controlled Trial" Nutrients 11, no. 1: 101. https://doi.org/10.3390/nu11010101

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop