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Bergamot Polyphenol Fraction Exerts Effects on Bone Biology by Activating ERK 1/2 and Wnt/β-Catenin Pathway and Regulating Bone Biomarkers in Bone Cell Cultures

1
Department of Medical and Surgical Science, University Magna Grecia, 88100 Catanzaro, Italy
2
Department of Health Science, University Magna Grecia, 88100 Catanzaro, Italy
3
Department of Molecular and Clinical Medicine, University of Gothenburg, 40530 Gothenburg, Sweden
4
Department of Clinical and Experimental Medicine, Nutrition Unit, University Magna Grecia, 88100 Catanzaro, Italy
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(9), 1305; https://doi.org/10.3390/nu10091305
Received: 31 July 2018 / Revised: 5 September 2018 / Accepted: 11 September 2018 / Published: 14 September 2018
Epidemiological studies show that fruit consumption may modulate bone mineral density. However, data regarding the effect of the Citrus bergamia Risso (Bergamot orange), a citrus fruit containing a high concentration of flavonoids, on bone health are still lacking. In this study, we investigated the effects of Bergamot polyphenols on the Wnt/β-catenin pathway in two distinct bone cell types (Saos-2 and MG63). Findings showed that exposure to 0.01 and 0.1 mg/mL doses upregulate β-catenin expression (p = 0.001), osteoblast differentiation markers (e.g., RUNX2 and COL1A), and downregulate RANKL (p = 0.028), as compared to the control. Our results highlight, for the first time, that Bergamot polyphenols act on bone cells through the β-catenin pathway. In vivo studies are necessary to fully understand Bergamot’s role against bone resorption. View Full-Text
Keywords: polyphenols; citrus fruits; Bergamot; osteoporosis; Saos-2; bone cells; β-catenin polyphenols; citrus fruits; Bergamot; osteoporosis; Saos-2; bone cells; β-catenin
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Pujia, A.; Russo, C.; Maurotti, S.; Pujia, R.; Mollace, V.; Romeo, S.; Montalcini, T. Bergamot Polyphenol Fraction Exerts Effects on Bone Biology by Activating ERK 1/2 and Wnt/β-Catenin Pathway and Regulating Bone Biomarkers in Bone Cell Cultures. Nutrients 2018, 10, 1305.

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