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Nutrients 2018, 10(9), 1305; https://doi.org/10.3390/nu10091305

Bergamot Polyphenol Fraction Exerts Effects on Bone Biology by Activating ERK 1/2 and Wnt/β-Catenin Pathway and Regulating Bone Biomarkers in Bone Cell Cultures

1
Department of Medical and Surgical Science, University Magna Grecia, 88100 Catanzaro, Italy
2
Department of Health Science, University Magna Grecia, 88100 Catanzaro, Italy
3
Department of Molecular and Clinical Medicine, University of Gothenburg, 40530 Gothenburg, Sweden
4
Department of Clinical and Experimental Medicine, Nutrition Unit, University Magna Grecia, 88100 Catanzaro, Italy
*
Author to whom correspondence should be addressed.
Received: 31 July 2018 / Revised: 5 September 2018 / Accepted: 11 September 2018 / Published: 14 September 2018
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Abstract

Epidemiological studies show that fruit consumption may modulate bone mineral density. However, data regarding the effect of the Citrus bergamia Risso (Bergamot orange), a citrus fruit containing a high concentration of flavonoids, on bone health are still lacking. In this study, we investigated the effects of Bergamot polyphenols on the Wnt/β-catenin pathway in two distinct bone cell types (Saos-2 and MG63). Findings showed that exposure to 0.01 and 0.1 mg/mL doses upregulate β-catenin expression (p = 0.001), osteoblast differentiation markers (e.g., RUNX2 and COL1A), and downregulate RANKL (p = 0.028), as compared to the control. Our results highlight, for the first time, that Bergamot polyphenols act on bone cells through the β-catenin pathway. In vivo studies are necessary to fully understand Bergamot’s role against bone resorption. View Full-Text
Keywords: polyphenols; citrus fruits; Bergamot; osteoporosis; Saos-2; bone cells; β-catenin polyphenols; citrus fruits; Bergamot; osteoporosis; Saos-2; bone cells; β-catenin
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Pujia, A.; Russo, C.; Maurotti, S.; Pujia, R.; Mollace, V.; Romeo, S.; Montalcini, T. Bergamot Polyphenol Fraction Exerts Effects on Bone Biology by Activating ERK 1/2 and Wnt/β-Catenin Pathway and Regulating Bone Biomarkers in Bone Cell Cultures. Nutrients 2018, 10, 1305.

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