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Open AccessArticle

Quality of Prenatal and Childhood Diet Predicts Neurodevelopmental Outcomes among Children in Mexico City

1
Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, 17 East 102nd Street, New York, NY 10029, USA
2
Instituto Nacional de Salud Pública, Avenida Universidad 655, Santa María Ahuacatitlán, Cuernavaca 62100, Mexico
3
Columbia Mailman School of Public Health, 722 W 168th Street, New York, NY 10032, USA
4
Instituto Nacional de Perinatología, Montes Urales 800, Lomas Virreyes, Ciudad de México C.P. 11000, Mexico
5
Division of Chronic Disease Research across the Life course, Department of Population Medicine, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
6
Harvard Pilgrim Health Care Institute, Landmark Center, 401 Park Dr #401, Boston, MA 02215, USA
*
Author to whom correspondence should be addressed.
The two authors contributed equally for the manuscript.
Nutrients 2018, 10(8), 1093; https://doi.org/10.3390/nu10081093
Received: 17 July 2018 / Revised: 3 August 2018 / Accepted: 9 August 2018 / Published: 15 August 2018
Adequate nutrition is important for neurodevelopment. Although nutrients are ingested in combination, the impact of specific nutrients within the context of a nutrient mixture has not been studied with respect to health, such as neurodevelopment. Therefore, we examined the impact of prenatal and childhood nutrient mixtures on neurodevelopmental outcomes. Participants included mother–child pairs in the Programming Research in Obesity, Growth, Environment, and Social Stress (PROGRESS) prospective birth cohort in Mexico City. We assessed prenatal and child micro- and macronutrient profiles among 65 and 329 children, respectively, via food frequency questionnaires. Neurodevelopmental outcomes of 4–6 year-old children were measured using the McCarthy Scales of Children’s Abilities (MSCA). We conducted weighted quantile sum (WQS) regression analyses to calculate indices reflecting “good” and “poor” prenatal and childhood nutrition. After adjusting for maternal education, socioeconomic status, the Home Observation for Measurement of the Environment (HOME) score, and total caloric intake, the good prenatal and childhood nutrition indices predicted more favorable neurodevelopment, while both poor nutrition indices predicted poorer neurodevelopment. These associations were stronger in prenatal than childhood models. Monounsaturated fats predicted various neurodevelopmental abilities relatively strongly in both models. Prenatal and childhood consumption of combinations of beneficial nutrients may contribute to more favorable neurodevelopment. View Full-Text
Keywords: nutrition; neurodevelopment; micronutrients; macronutrients; nutrient mixtures nutrition; neurodevelopment; micronutrients; macronutrients; nutrient mixtures
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Malin, A.J.; Busgang, S.A.; Cantoral, A.J.; Svensson, K.; Orjuela, M.A.; Pantic, I.; Schnaas, L.; Oken, E.; Baccarelli, A.A.; Téllez-Rojo, M.M.; Wright, R.O.; Gennings, C. Quality of Prenatal and Childhood Diet Predicts Neurodevelopmental Outcomes among Children in Mexico City. Nutrients 2018, 10, 1093.

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