Relationships between Maternal Obesity and Maternal and Neonatal Iron Status
by
Angela C. Flynn 1,*
, Shahina Begum 1, Sara L. White 1, Kathryn Dalrymple 1, Carolyn Gill 1, Nisreen A. Alwan 2,3, Mairead Kiely 4,5, Gladys Latunde-Dada 6, Ruth Bell 7, Annette L. Briley 1, Scott M. Nelson 8, Eugene Oteng-Ntim 1, Jane Sandall 1, Thomas A. Sanders 6, Melissa Whitworth 9, Deirdre M. Murray 5,10, Louise C. Kenny 5,11, Lucilla Poston 1 and On behalf of the SCOPE and UPBEAT Consortiums
Angela C. Flynn 1,*, Shahina Begum 1, Sara L. White 1, Kathryn Dalrymple 1, Carolyn Gill 1, Nisreen A. Alwan 2,3, Mairead Kiely 4,5, Gladys Latunde-Dada 6, Ruth Bell 7, Annette L. Briley 1, Scott M. Nelson 8, Eugene Oteng-Ntim 1, Jane Sandall 1, Thomas A. Sanders 6, Melissa Whitworth 9, Deirdre M. Murray 5,10, Louise C. Kenny 5,11, Lucilla Poston 1 and On behalf of the SCOPE and UPBEAT Consortiums
1
Department of Women and Children’s Health, Faculty of Life Sciences and Medicine, King’s College London, 10th Floor North Wing St Thomas’ Hospital, London SE1 7EH, UK
2
Academic Unit of Primary Care and Population Sciences, Faculty of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK
3
NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK
4
School of Food and Nutritional Sciences, Food Science Building, University College Cork, T12 Y337 Cork, Ireland
5
The Irish Centre for Fetal and Neonatal Translational Research (INFANT), Department of Obstetrics and Gynaecology, University College Cork, T12 Y337 Cork, Ireland
6
Department of Nutritional Sciences, King’s College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 7EH, UK
7
Institute of Health & Society, Baddiley-Clark Building, Richardson Road, Newcastle upon Tyne NE2 4AX, UK
8
School of Medicine, University of Glasgow, New Lister Building, Glasgow Royal Infirmary, Glasgow G31 2ER, UK
9
Manchester University NHS Foundation Trust, St Mary’s Hospital, Manchester M13 9WL, UK
10
Department of Paediatrics & Child Health, University College Cork, T12 Y337 Cork, Ireland
11
Department of Obstetrics and Gynaecology, University College Cork, T12 Y337 Cork, Ireland
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(8), 1000; https://doi.org/10.3390/nu10081000
Received: 26 June 2018 / Revised: 20 July 2018 / Accepted: 24 July 2018 / Published: 30 July 2018
(This article belongs to the Special Issue Nutrient Requirements and Dietary Intakes of Women during Pregnancy)
Obesity in pregnancy may negatively influence maternal and infant iron status. The aim of this study was to examine the association of obesity with inflammatory and iron status in both mother and infant in two prospective studies in pregnancy: UPBEAT and SCOPE. Maternal blood samples from obese (n = 245, BMI ≥ 30 kg/m2) and normal weight (n = 245, BMI < 25 kg/m2) age matched pregnant women collected at approximately 15 weeks’ gestation, and umbilical cord blood samples collected at delivery, were analysed for a range of inflammatory and iron status biomarkers. Concentrations of C- reactive protein and Interleukin-6 in obese women compared to normal weight women were indicative of an inflammatory response. Soluble transferrin receptor (sTfR) concentration [18.37 nmol/L (SD 5.65) vs. 13.15 nmol/L (SD 2.33)] and the ratio of sTfR and serum ferritin [1.03 (SD 0.56) vs. 0.69 (SD 0.23)] were significantly higher in obese women compared to normal weight women (P < 0.001). Women from ethnic minority groups (n = 64) had higher sTfR concentration compared with white women. There was no difference in maternal hepcidin between obese and normal weight women. Iron status determined by cord ferritin was not statistically different in neonates born to obese women compared with neonates born to normal weight women when adjusted for potential confounding variables. Obesity is negatively associated with markers of maternal iron status, with ethnic minority women having poorer iron statuses than white women.
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Keywords:
pregnancy; obesity; inflammation; iron status
This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited
MDPI and ACS Style
Flynn, A.C.; Begum, S.; White, S.L.; Dalrymple, K.; Gill, C.; Alwan, N.A.; Kiely, M.; Latunde-Dada, G.; Bell, R.; Briley, A.L.; Nelson, S.M.; Oteng-Ntim, E.; Sandall, J.; Sanders, T.A.; Whitworth, M.; Murray, D.M.; Kenny, L.C.; Poston, L.; , O.S.U.C. Relationships between Maternal Obesity and Maternal and Neonatal Iron Status. Nutrients 2018, 10, 1000.
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