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Nutrients 2018, 10(2), 184;

Vitamin D-Binding Protein Polymorphisms, 25-Hydroxyvitamin D, Sunshine and Multiple Sclerosis

Los Angeles Medical Center, Neurology Department, Southern California Permanente Medical Group, 1505 N Edgemont Street, Los Angeles, CA 90027, USA
College of Medicine, Biology & Environment, Australian National University, Canberra, ACT 2000, Australia
Department of Research & Evaluation, Kaiser Permanente Southern California, 100 S. Los Robles Avenue, Pasadena, CA 91101, USA
Philadelphia College of Osteopathic Medicine, 4000 Presidential Blvd., Apt. 819, Philadelphia, PA 19131, USA
QB3 Genetic Epidemiology and Genomics Lab, School of Public Health, University of California Berkeley, 209 Hildebrand Hall, Berkeley, CA 94720, USA
Author to whom correspondence should be addressed.
Received: 9 January 2018 / Revised: 1 February 2018 / Accepted: 2 February 2018 / Published: 7 February 2018
(This article belongs to the Special Issue Changing Times for Vitamin D and Health)
Full-Text   |   PDF [444 KB, uploaded 7 February 2018]   |  


Blacks have different dominant polymorphisms in the vitamin D-binding protein (DBP) gene that result in higher bioavailable vitamin D than whites. This study tested whether the lack of association between 25-hydroxyvitamin D (25OHD) and multiple sclerosis (MS) risk in blacks and Hispanics is due to differences in these common polymorphisms (rs7041, rs4588). We recruited incident MS cases and controls (blacks 116 cases/131 controls; Hispanics 183/197; whites 247/267) from Kaiser Permanente Southern California. AA is the dominant rs7041 genotype in blacks (70.0%) whereas C is the dominant allele in whites (79.0% AC/CC) and Hispanics (77.1%). Higher 25OHD levels were associated with a lower risk of MS in whites who carried at least one copy of the C allele but not AA carriers. No association was found in Hispanics or blacks regardless of genotype. Higher ultraviolet radiation exposure was associated with a lower risk of MS in blacks (OR = 0.06), Hispanics and whites who carried at least one copy of the C allele but not in others. Racial/ethnic variations in bioavailable vitamin D do not explain the lack of association between 25OHD and MS in blacks and Hispanics. These findings further challenge the biological plausibility of vitamin D deficiency as causal for MS. View Full-Text
Keywords: multiple sclerosis; vitamin D; polymorphisms; blacks; Hispanics multiple sclerosis; vitamin D; polymorphisms; blacks; Hispanics

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Langer-Gould, A.; Lucas, R.M.; Xiang, A.H.; Wu, J.; Chen, L.H.; Gonzales, E.; Haraszti, S.; Smith, J.B.; Quach, H.; Barcellos, L.F. Vitamin D-Binding Protein Polymorphisms, 25-Hydroxyvitamin D, Sunshine and Multiple Sclerosis. Nutrients 2018, 10, 184.

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