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Open AccessArticle

Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants

1
Institut National de la Recherche Agronomique (INRA), Unité Mixte de Recherche (UMR) 1280, Physiopathologie des Adaptations Nutritionnelles, Institut des Maladies de L’appareil Digestif (IMAD), Centre de Recherche en Nutrition Humaine Ouest (CRNH), 44093 Nantes, CEDEX 1, France
2
Statistique, Sensométrie et Chimiométrie (StatSC), Ecole Nationale Vétérinaire, Agroalimentaire et de l’Alimentation Nantes-Atlantique (ONIRIS), Institut National de la Recherche Agronomique (INRA), 44322 Nantes, France
3
L’Université Nantes Angers Le Mans (LUNAM Université), Ecole Nationale Vétérinaire, Agroalimentaire et de l'Alimentation Nantes-Atlantique (ONIRIS), Laboratoire d’Etude des Résidus et Contaminants dans les Aliments (LABERCA), USC INRA 1329, 44200 Nantes, France
4
Faculté de Médicine de Nantes, Centre Hospitalo-Universitaire Hôtel-Dieu (CHU), 44093 Nantes, France
5
European Milk Bank Association (EMBA), 20126 Milan, Italy
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2018, 10(2), 164; https://doi.org/10.3390/nu10020164
Received: 11 December 2017 / Revised: 12 January 2018 / Accepted: 12 January 2018 / Published: 31 January 2018
Human milk is recommended for feeding preterm infants. The current pilot study aims to determine whether breast-milk lipidome had any impact on the early growth-pattern of preterm infants fed their own mother’s milk. A prospective-monocentric-observational birth-cohort was established, enrolling 138 preterm infants, who received their own mother’s breast-milk throughout hospital stay. All infants were ranked according to the change in weight Z-score between birth and hospital discharge. Then, we selected infants who experienced “slower” (n = 15, −1.54 ± 0.42 Z-score) or “faster” (n = 11, −0.48 ± 0.19 Z-score) growth; as expected, although groups did not differ regarding gestational age, birth weight Z-score was lower in the “faster-growth” group (0.56 ± 0.72 vs. −1.59 ± 0.96). Liquid chromatography–mass spectrometry lipidomic signatures combined with multivariate analyses made it possible to identify breast-milk lipid species that allowed clear-cut discrimination between groups. Validation of the selected biomarkers was performed using multidimensional statistical, false-discovery-rate and ROC (Receiver Operating Characteristic) tools. Breast-milk associated with faster growth contained more medium-chain saturated fatty acid and sphingomyelin, dihomo-γ-linolenic acid (DGLA)-containing phosphethanolamine, and less oleic acid-containing triglyceride and DGLA-oxylipin. The ability of such biomarkers to predict early-growth was validated in presence of confounding clinical factors but remains to be ascertained in larger cohort studies. View Full-Text
Keywords: breast milk lipidome; preterm infant; growth trajectory breast milk lipidome; preterm infant; growth trajectory
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Alexandre-Gouabau, M.-C.; Moyon, T.; Cariou, V.; Antignac, J.-P.; Qannari, E.M.; Croyal, M.; Soumah, M.; Guitton, Y.; David-Sochard, A.; Billard, H.; Legrand, A.; Boscher, C.; Darmaun, D.; Rozé, J.-C.; Boquien, C.-Y. Breast Milk Lipidome Is Associated with Early Growth Trajectory in Preterm Infants. Nutrients 2018, 10, 164.

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