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Contrasting Effects of Short-Term Mediterranean and Vegan Diets on Microvascular Function and Cholesterol in Younger Adults: A Comparative Pilot Study

1
Academy of Sport and Physical Activity, Sheffield Hallam University, Sheffield S10 2BP, UK
2
The University of Sheffield, Sheffield S10 2RX, UK
3
Centre for Sport and Exercise Sciences, Sheffield Hallam University, Sheffield S10 2BP, UK
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(12), 1897; https://doi.org/10.3390/nu10121897
Received: 16 October 2018 / Revised: 22 November 2018 / Accepted: 23 November 2018 / Published: 3 December 2018
The Mediterranean diet has been shown to improve cardiovascular health. Vegan diets have demonstrated similar benefits, albeit in fewer studies. In a comparative pilot study, we compared the effects of a short-term Mediterranean Diet (MD) and Vegan Diet (VD) on microvascular function and cholesterol levels in a healthy population. Twenty-four young (aged 18 to 35 years) healthy volunteers followed a four-week intervention (MD = 12; VD = 12) ad libitum. Pre and post-intervention anthropometrics, microvascular function (assessed via LDF and expressed as raw CVC and %CVC MAX), dietary-analysis data (Calories, Protein, Carbohydrates, Total Fat, Saturated Fat, Fibre), Mean Arterial Pressure (MAP), Blood Pressure, Total Cholesterol (TC), High Density Lipoprotein (HDL-C) and TC:HDL-C were compared. MD participants reduced Total Fat intake (p = 0.05). Saturated Fat decreased (MD: p = < 0.001; VD: p = 0.004) and Fibre increased (MD: p = 0.02; VD: p = < 0.001) in both groups. Dietary changes reflected improvements in plateau raw CVC in the MD group (p = 0.005), and a reduction in TC (p = 0.045) and weight loss (p = 0.047) in the VD group. The MD led to improvements in microvascular function; the VD led to reduced TC and weight loss. Although both diets might offer CVD risk-reduction benefits, evidence for the MD appeared to be stronger due to changes in vasodilatory ability and NO bioavailability. View Full-Text
Keywords: vegan diet; mediterranean diet; microvascular function; laser doppler flowmetry; cholesterol; cardiovascular disease vegan diet; mediterranean diet; microvascular function; laser doppler flowmetry; cholesterol; cardiovascular disease
MDPI and ACS Style

Rogerson, D.; Maçãs, D.; Milner, M.; Liu, Y.; Klonizakis, M. Contrasting Effects of Short-Term Mediterranean and Vegan Diets on Microvascular Function and Cholesterol in Younger Adults: A Comparative Pilot Study. Nutrients 2018, 10, 1897. https://doi.org/10.3390/nu10121897

AMA Style

Rogerson D, Maçãs D, Milner M, Liu Y, Klonizakis M. Contrasting Effects of Short-Term Mediterranean and Vegan Diets on Microvascular Function and Cholesterol in Younger Adults: A Comparative Pilot Study. Nutrients. 2018; 10(12):1897. https://doi.org/10.3390/nu10121897

Chicago/Turabian Style

Rogerson, David, Diana Maçãs, Marianne Milner, Yingshan Liu, and Markos Klonizakis. 2018. "Contrasting Effects of Short-Term Mediterranean and Vegan Diets on Microvascular Function and Cholesterol in Younger Adults: A Comparative Pilot Study" Nutrients 10, no. 12: 1897. https://doi.org/10.3390/nu10121897

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