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Nutrients 2018, 10(12), 1862; https://doi.org/10.3390/nu10121862

A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions

1
National Institute of Gastroenterology “S. de Bellis”, Institute of Research, 70013 Castellana Grotte (BA), Italy
2
Department of Pharmacy, School of Pharmacy, University of Salerno, 84084 Fisciano (SA), Italy
3
Institute of Sciences of Food Production C.N.R., Unit of Lecce, 73100 Lecce, Italy
4
Department of Soil, Plant and Food Sciences, University of Bari, 70126 Bari, Italy
5
School of Pharmacy, University of East Anglia, Norwich Research Park, Norwich NR4 7TJ, UK
6
John Innes Centre, Colney Research Park, Norwich NR4 7UH, UK
These authors contributed equally to the paper.
*
Author to whom correspondence should be addressed.
Received: 31 October 2018 / Revised: 22 November 2018 / Accepted: 24 November 2018 / Published: 2 December 2018
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Abstract

Inflammatory bowel diseases (IBD) are debilitating chronic inflammatory disorders that develop as a result of a defective immune response toward intestinal bacteria. Intestinal dysbiosis is associated with the onset of IBD and has been reported to persist even in patients in deep remission. We investigated the possibility of a dietary-induced switch to the gut microbiota composition using Winnie mice as a model of spontaneous ulcerative colitis and chow enriched with 1% Bronze tomato. We used the near isogenic tomato line strategy to investigate the effects of a diet enriched in polyphenols administered to mild but established chronic intestinal inflammation. The Bronze-enriched chow administered for two weeks was not able to produce any macroscopic effect on the IBD symptoms, although, at molecular level there was a significant induction of anti-inflammatory genes and intracellular staining of T cells revealed a mild decrease in IL17A and IFNγ production. Analysis of the microbial composition revealed that two weeks of Bronze enriched diet was sufficient to perturb the microbial composition of Winnie and control mice, suggesting that polyphenol-enriched diets may create unfavorable conditions for distinct bacterial species. In conclusion, dietary regimes enriched in polyphenols may efficiently support IBD remission affecting the intestinal dysbiosis. View Full-Text
Keywords: microbiota; inflammatory bowel disease (IBD); polyphenols; bronze tomatoes; murine models microbiota; inflammatory bowel disease (IBD); polyphenols; bronze tomatoes; murine models
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Liso, M.; De Santis, S.; Scarano, A.; Verna, G.; Dicarlo, M.; Galleggiante, V.; Campiglia, P.; Mastronardi, M.; Lippolis, A.; Vacca, M.; Sobolewski, A.; Serino, G.; Butelli, E.; De Angelis, M.; Martin, C.; Santino, A.; Chieppa, M. A Bronze-Tomato Enriched Diet Affects the Intestinal Microbiome under Homeostatic and Inflammatory Conditions. Nutrients 2018, 10, 1862.

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