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Deciphering the Role of the Non-Coding Genome in Regulating Gene-Diet Interactions

Department of Medical and Molecular Genetics, School of Basic and Medical Biosciences, King’s College London, London SE1 9RT, UK
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Author to whom correspondence should be addressed.
Nutrients 2018, 10(12), 1831; https://doi.org/10.3390/nu10121831
Received: 24 October 2018 / Revised: 19 November 2018 / Accepted: 21 November 2018 / Published: 27 November 2018
(This article belongs to the Special Issue Gene-Diet Interactions)
Protein encoding genes constitute a small fraction of mammalian genomes. In addition to the protein coding genes, there are other functional units within the genome that are transcribed, but not translated into protein, the so called non-coding RNAs. There are many types of non-coding RNAs that have been identified and shown to have important roles in regulating gene expression either at the transcriptional or post-transcriptional level. A number of recent studies have highlighted that dietary manipulation in mammals can influence the expression or function of a number of classes of non-coding RNAs that contribute to the protein translation machinery. The identification of protein translation as a common target for nutritional regulation underscores the need to investigate how this may mechanistically contribute to phenotypes and diseases that are modified by nutritional intervention. Finally, we describe the state of the art and the application of emerging ‘-omics’ technologies to address the regulation of protein translation in response to diet. View Full-Text
Keywords: non-coding RNA; gene-diet interaction; omics; epigenetics; epitranscriptome; RNA modifications; ribosome; protein translation non-coding RNA; gene-diet interaction; omics; epigenetics; epitranscriptome; RNA modifications; ribosome; protein translation
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MDPI and ACS Style

Law, P.-P.; Holland, M.L. Deciphering the Role of the Non-Coding Genome in Regulating Gene-Diet Interactions. Nutrients 2018, 10, 1831. https://doi.org/10.3390/nu10121831

AMA Style

Law P-P, Holland ML. Deciphering the Role of the Non-Coding Genome in Regulating Gene-Diet Interactions. Nutrients. 2018; 10(12):1831. https://doi.org/10.3390/nu10121831

Chicago/Turabian Style

Law, Pui-Pik, and Michelle L. Holland 2018. "Deciphering the Role of the Non-Coding Genome in Regulating Gene-Diet Interactions" Nutrients 10, no. 12: 1831. https://doi.org/10.3390/nu10121831

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