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Article

Effects of Royal Jelly Administration on Endurance Training-Induced Mitochondrial Adaptations in Skeletal Muscle

Department of Sports Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan
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Nutrients 2018, 10(11), 1735; https://doi.org/10.3390/nu10111735
Received: 17 October 2018 / Revised: 8 November 2018 / Accepted: 9 November 2018 / Published: 12 November 2018
We investigated the effect of royal jelly (RJ), a natural secretion from worker bees, on the endurance training-induced mitochondrial adaptations in skeletal muscles of ICR mice. Mice received either RJ (1.0 mg/g body weight) or distilled water for three weeks. The mice in the training group were subjected to endurance training (20 m/min; 60 min; 5 times/week). There was a main effect of endurance training on the maximal activities of the mitochondrial enzymes, citrate synthase (CS), and β-hydroxyacyl coenzyme Adehydrogenase (β-HAD), in the plantaris and tibialis anterior (TA) muscles, while no effect of RJ treatment was observed. In the soleus muscle, CS and β-HAD maximal activities were significantly increased by endurance training in the RJ-treated group, while there was no effect of training in the control group. Furthermore, we investigated the effects of acute RJ treatment on the signaling cascade involved in mitochondrial biogenesis. In the soleus, phosphorylation of 5′-AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) were additively increased by a single RJ treatment and endurance exercise, while only an exercise effect was found in the plantaris and TA muscles. These results indicate that the RJ treatment induced mitochondrial adaptation with endurance training by AMPK activation in the soleus muscles of ICR mice. View Full-Text
Keywords: endurance training; mitochondrial enzymes; phospho-AMPK; royal jelly; skeletal muscle endurance training; mitochondrial enzymes; phospho-AMPK; royal jelly; skeletal muscle
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MDPI and ACS Style

Takahashi, Y.; Hijikata, K.; Seike, K.; Nakano, S.; Banjo, M.; Sato, Y.; Takahashi, K.; Hatta, H. Effects of Royal Jelly Administration on Endurance Training-Induced Mitochondrial Adaptations in Skeletal Muscle. Nutrients 2018, 10, 1735. https://doi.org/10.3390/nu10111735

AMA Style

Takahashi Y, Hijikata K, Seike K, Nakano S, Banjo M, Sato Y, Takahashi K, Hatta H. Effects of Royal Jelly Administration on Endurance Training-Induced Mitochondrial Adaptations in Skeletal Muscle. Nutrients. 2018; 10(11):1735. https://doi.org/10.3390/nu10111735

Chicago/Turabian Style

Takahashi, Yumiko; Hijikata, Kamiyu; Seike, Kohei; Nakano, Suguru; Banjo, Mai; Sato, Yosuke; Takahashi, Kenya; Hatta, Hideo. 2018. "Effects of Royal Jelly Administration on Endurance Training-Induced Mitochondrial Adaptations in Skeletal Muscle" Nutrients 10, no. 11: 1735. https://doi.org/10.3390/nu10111735

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