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Nutrients 2018, 10(10), 1548; https://doi.org/10.3390/nu10101548

Low-Salt Intake Suggestions in Hypertensive Patients Do not Jeopardize Urinary Iodine Excretion

Centre for Secondary Hypertension, Unit of Clinical Endocrinology, Department of Internal Medicine, University of Genoa Medical School, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy
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Received: 17 September 2018 / Revised: 5 October 2018 / Accepted: 17 October 2018 / Published: 19 October 2018
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Abstract

A low-sodium diet is an essential part of the treatment of hypertension. However, some concerns have been raised with regard to the possible reduction of iodine intake during salt restriction. We obtained 24-h urine collections for the evaluation of iodine (UIE) and sodium excretion (UNaV) from 136 hypertensive patients, before and after 9 ± 1 weeks of a simple low-sodium diet. Body mass index (BMI), blood pressure (BP), and drug consumption (DDD) were recorded. Data are average ± SEM. Age was 63.6 ± 1.09 year. BMI was 25.86 ± 0.40 kg/m2 before the diet and 25.38 ± 0.37 kg/m2 after the diet (p < 0.05). UNaV decreased from 150.3 ± 4.01 mEq/24-h to 122.8 ± 3.92 mEq/24-h (p < 0.001); UIE decreased from 186.1 ± 7.95 µg/24-h to 175.0 ± 7.74 µg/24-h (p = NS); both systolic and diastolic BP values decreased (by 6.15 ± 1.32 mmHg and by 3.75 ± 0.84 mmHg, respectively, p < 0.001); DDD decreased (ΔDDD 0.29 ± 0.06, p < 0.05). UNaV and UIE were related both before (r = 0.246, p = 0.0040) and after the diet (r = 0.238, p = 0.0050). UNaV and UIE were significantly associated both before and after the diet (p < 0.0001 for both). After salt restriction UIE showed a non-significant decrease remaining in an adequate range. Our dietary suggestions were aimed at avoiding preserved foods, whereas the cautious use of table salt was permitted, an approach which seems safe in terms of iodine intake. View Full-Text
Keywords: blood pressure; dietary sodium; hypertension; iodine; salt blood pressure; dietary sodium; hypertension; iodine; salt
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Musso, N.; Conte, L.; Carloni, B.; Campana, C.; Chiusano, M.C.; Giusti, M. Low-Salt Intake Suggestions in Hypertensive Patients Do not Jeopardize Urinary Iodine Excretion. Nutrients 2018, 10, 1548.

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