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Nutrients 2018, 10(10), 1546; https://doi.org/10.3390/nu10101546

The Effects of Adjuvant Fermented Wheat Germ Extract on Cancer Cell Lines: A Systematic Review

Department of Clinical and Experimental Medicine, University of Foggia, 71122 Foggia, Italy
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Received: 20 September 2018 / Revised: 11 October 2018 / Accepted: 15 October 2018 / Published: 19 October 2018
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Abstract

Fermented wheat germ extract (FWGE; trade name AVEMAR) is a natural compound derived from industrial fermentation of wheat germ. Its potential anticancer properties has emerged from recent studies. The aim of this systematic review is to summarize the data available in the scientific literature concerning the in vitro activity of FWGE on malignant cells. A systematic review of English articles in electronic databases has been performed. The primary outcomes of the review regarded types of cancer cell lines subjected to the investigation and the main results concerning cell viability, proliferation, and apoptosis observed within the studies. Sixteen articles were included in the final qualitative analysis. Various types of cancer cells treated with FWGE have been analyzed, showing mainly cytotoxic effects, alteration of the cell cycle, antiproliferative effects, and induction of apoptosis. FWGE can be a promising drug component in cancer treatment; however, further in vitro and in vivo studies are necessary to prove its effectiveness and safety in humans. View Full-Text
Keywords: FWGE; AVEMAR; fermented wheat germ extract; nutraceuticals; cancer treatment FWGE; AVEMAR; fermented wheat germ extract; nutraceuticals; cancer treatment
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Zhurakivska, K.; Troiano, G.; Caponio, V.C.A.; Dioguardi, M.; Arena, C.; Lo Muzio, L. The Effects of Adjuvant Fermented Wheat Germ Extract on Cancer Cell Lines: A Systematic Review. Nutrients 2018, 10, 1546.

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