|Comin-Anduix et al. ||2002||Fermented Wheat Germ Extract Inhibits Glycolysis/Pentose|
Cycle Enzymes and Induces Apoptosis through Poly (ADP-ribose) Polymerase Activation in Jurkat T-cell Leukemia Tumor Cells.
|Jurkat T-cell Leukemia Tumor Cells.||Cell cycle analysis, cell viability assay, assessment of apoptosis.||Cytotoxic effects, alteration of the cell cycle, induction of apoptosis.||Cleavage of PARP, Transketolase, G6PDH, HK, LDH inhibition. |
|Fajka-boja et al. ||2002||Fermented wheat germ extract induces apoptosis and downregulation of major histocompatibility complex class I proteins in tumor T and B cell lines.||Jurkat leukemic T cells, Burkitt lymphoma B cell lines, myelo-monocytic cell line.||Detection of apoptotic cells, measurement of cell proliferation.||Induction of apoptosis, antiproliferative effect.||Elevation of intracellular Ca2+ concentration.|
|Imir et al. ||2018||Mechanism of the anti-angiogenic effect of AVEMAR on tumor cells.||NCI-N87 (gastric tubular adenocarcinoma), PC3 (prostate carcinoma), HeLa (adenocarcinoma) and A549 (lung adenocarcinoma)||Investigation of anti-angiogenic effects.||Inhibition of induced VEGF levels.||Inhibition of Cox-2 levels.|
|Judson et al. ||2012||Characterizing the efficacy of fermented wheat germ extract against ovarian cancer and defining the genomic basis of its activity.||Ovarian cancer cell lines.||Cell viability assays.||Cytotoxic effects, increase of cisplatin sensitivity.|| |
|Marcsek et al. ||2004||The Efficacy of Tamoxifen in Estrogen Receptor–Positive Breast Cancer Cells Is Enhanced by a Medical Nutriment.||MCF-7 breast cancer cells.||Cytotoxic effects evaluation, detection of apoptosis and mitosis, evaluation of tamoxifen-combined treatment.||Cytotoxicity, induction of apoptosis.|| |
|Mueller et al. ||2011||Promising cytotoxic activity profile of fermented wheat germ extract (Avemar®) in human cancer cell lines.||testicular cancer (H12.1, 2102EP, 1411HP, 1777NRpmet), colon cancer (HCT-8, HCT-15, HCT-116, HT-29, DLD-1, SW480, COLO205, COLO320DM), NSCLC (A549, A427, H322, H358), head and neck cancer (FADU, A253), cervical epidermoid|
carcinoma (A431), mammary adenocarcinoma (MCF-7, BT474), ovarian adenocarcinoma (A2780), gastric Cancer (M2), anaplastic thyroid cancer (8505C, SW1736), papillary thyroid cancer (BCPAP), follicular thyroid cancer (FTC133), melanoma, hepatoma (HepG2), glioblastoma (U87MG), neuroblastoma (SHSY5Y, SIMA).
|Growth inhibition experiments, apoptosis evaluation. ||Antiproliferative activity.|| |
|Otto et al. ||2016||Antiproliferative and antimetabolic effects behind the anticancer property of fermented wheat germ extract.||Adenocarcinoma of the breast (MDA-MB-468) and (MDA-MB-231) and (BT-20), adenocarcinoma of the pancreas (ASPC-1) and (BxPC-3), adenocarcinoma of the stomach (23132/87), adenocarcinoma of the colon (HT-29) and (HRT-18), invasive breast ductal carcinoma (MCF-7).||Effects on cell growth, Cell cycle analysis.||Cytotoxic, antiproliferative and growth delay effects.||Depletion in cellular ATP and decrease in the NADH/NAD+ ratio.|
Impaired glucose consumption and significantly reduced production of lactic acid.
Induction of autophagy in HRT-18 cells.
|Saiko et al. ||2007||Avemar, a nontoxic fermented wheat germ extract, induces apoptosis and inhibits ribonucleotide reductase in human HL-60 promyelocytic leukemia cells.||Human HL-60 promyelocytic leukemia cells.||Apoptosis evaluation, cell cycle distribution analysis.||Induction of apoptosis, cell growth inhibition.||Decreasing of dNTPs, direct enzyme attenuation (ribonucleotide reductase; RR).|
|Saiko et al. ||2009||Avemar, a nontoxic fermented wheat germ extract, attenuates the growth of sensitive and 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cells through induction of apoptosis.||Human lymphoma cells H9, 5-FdUrd/Ara-C cross-resistant H9 human lymphoma cell line.||Growth inhibition assay, apoptosis evaluation.||Growth inhibition, induction of apoptosis.|| |
|Tai et al. ||2013||Fermented Wheat Germ Extract Induced Cell Death and Enhanced Cytotoxicity of Cisplatin and 5-Fluorouracil on Human Hepatocellular Carcinoma Cells.||Hepatocellular carcinoma (HCC) HepG2, Hep3B, and HepJ5 cells.||Cell viability Assay, evaluation of cisplatin and 5-fluorouracil combined treatment.||Antiproliferative activity, enhanced cytotoxicity of chemotherapeutic.|| |
|Wang et al. ||2015||Preclinical Evaluation on the Tumor Suppression Efficiency and Combination Drug Effects of Fermented Wheat Germ Extract in Human Ovarian Carcinoma Cells.||SKOV-3 and ES-2 human ovarian carcinoma cells.||Cell viability evaluation, cell death markers analysis, evaluation of cisplatin- or docetaxel-combined treatment.||Suppression of cell proliferation, caspase-related apoptosis activation, increased cytotoxicity of cisplatin and docetaxel.|| |
|Yang et al. ||2016||Inhibitory Effects of AVEMAR on Proliferation and Metastasis of Oral Cancer Cells.||Human oral squamous carcinoma SCC-4 cells.||Cell viability evaluation, cell apoptosis assay wound-healing migration assay, cell invasion assay.||Inhibition of cell viability, induction of cell apoptosis, suppression of migration and invasion capacity.|| |
|Zhang et al. ||2015||Effect of Fermented Wheat Germ Extract with Lactobacillus plantarum dy-1 on HT-29 Cell Proliferation and Apoptosis.||Human HT-29 colon cancer cells.||Growth inhibition assay, assessment of apoptosis.||High antiproliferative effects, induction of cell apoptosis.|| |
|Barisone et al. ||2017||A purified, fermented, extract of Triticum aestivum has lymphomacidal activity mediated via natural killer cell activation.||Lymphoma cells, T-cell leukemia (Jurkat), lung (H1650), breast (MCF-7) and hepatic (HepG2) cancer cell lines.||Cytotoxic activity assay, apoptosis and cell cycle.||Cytotoxic activity, apoptotic activity.|| |
|Szende et al. ||2004||Effect of Simultaneous Administration of Avemar® and Cytostatic Drugs on Viability of Cell Cultures, Growth of Experimental Tumors, and Survival of Tumor-Bearing Mice.||Human breast adenocarcinoma cell line (MCF-7), hepatocyte carcinoma (HepG2).||Cytotoxicity testing of Avemar associated with various cytostatic drugs (5 FU, Dacarbazine, Adriblastina).||Did not increase nor decrease cell viability.|| |
|Boros et al. ||2001||Wheat Germ Extract Decreases Glucose Uptake and RNA|
Ribose Formation but Increases Fatty Acid Synthesis in MIA
Pancreatic Adenocarcinoma Cells.
|MIA pancreatic adenocarcinoma cells.||Evaluation of glucose utilization rates and lactate production.||Regulation of tumor cell proliferation.||Inhibitory effect on glucose consumption, little effect on lactate production.|