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Nutrients 2018, 10(10), 1495; https://doi.org/10.3390/nu10101495

Chronic Intake of Micrograms of Abscisic Acid Improves Glycemia and Lipidemia in a Human Study and in High-Glucose Fed Mice

1
Department of Experimental Medicine (DIMES), University of Genova, Viale Benedetto XV 1, 16132 Genova, Italy
2
Nutravis S.r.l., Via Corsica 2/9, 16128 Genova, Italy
3
Department of Internal Medicine, IRCCS Ospedale San Martino, Largo R. Benzi 1, 16132 Genova, Italy
4
Animal Facility, IRCCS Ospedale San Martino, Largo R. Benzi 1, 16132 Genova, Italy
*
Authors to whom correspondence should be addressed.
Received: 10 September 2018 / Revised: 19 September 2018 / Accepted: 8 October 2018 / Published: 12 October 2018
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Abstract

We tested the effect of chronic low-dose abscisic acid (ABA), a phytohormone-regulating human glucose tolerance, on the metabolic parameters that are dysregulated in prediabetes and metabolic syndrome (MS).Ten healthy subjects received 1 µg ABA/Kg body weight (BW)/day as an ABA-rich food supplement: (i) the glycemia profile after a carbohydrate-rich meal, with or without supplement, was compared; (ii) fasting blood glucose (FBG), glycated hemoglobin (HbA1c), total cholesterol (TC), and body mass index (BMI) after 75 days of daily supplementation of a habitual Mediterranean diet were compared with starting values.CD1 mice were fed a high-glucose diet with or without synthetic ABA (1 µg/Kg BW) for 4 months and the same parameters investigated in the human study were compared. The food supplement significantly reduced the area under the curve of glycemia after a carbohydrate-rich meal and FBG, HbA1c, TC, and BMI after chronic treatment. ABA-treated mice showed a significant reduction of HbA1c, TC, and body weight gain compared with untreated controls. The combined results from the human and murine studies allow us to conclude that the observed improvement of the metabolic parameters can be attributed to ABA and to advocate the use of ABA-containing food supplements in prediabetes and/or MS. View Full-Text
Keywords: prediabetes; metabolic syndrome; food supplement; glucose tolerance; cardiovascular risk prediabetes; metabolic syndrome; food supplement; glucose tolerance; cardiovascular risk
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Magnone, M.; Leoncini, G.; Vigliarolo, T.; Emionite, L.; Sturla, L.; Zocchi, E.; Murialdo, G. Chronic Intake of Micrograms of Abscisic Acid Improves Glycemia and Lipidemia in a Human Study and in High-Glucose Fed Mice. Nutrients 2018, 10, 1495.

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