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Nutrients 2018, 10(10), 1454; https://doi.org/10.3390/nu10101454

Impact of Blood or Erythrocyte Membrane Fatty Acids for Disease Risk Prediction: Focusing on Cardiovascular Disease and Chronic Kidney Disease

1,2,†
,
3,†
and
3,*
1
Department of Food Science and Nutrition, Dong-A University, Busan 49315, Korea
2
Center for Silver-targeted Biomaterials, Brain Busan 21 Plus Program, Graduate School, Dong-A University, Busan 49315, Korea
3
Department of Internal Medicine, Dong-A University, Busan 49201, Korea
O.Y.K. and S.M.L. contributed equally to this work.
*
Author to whom correspondence should be addressed.
Received: 30 August 2018 / Revised: 2 October 2018 / Accepted: 4 October 2018 / Published: 7 October 2018
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Abstract

Fatty acids (FAs) are essential nutrients and main constituents of cell membranes that are involved in the signaling pathway and associated with health conditions. We investigated if blood or erythrocyte membrane FAs can predict the risk of cardiovascular disease (CVD), chronic kidney disease (CKD), and related complications. Omega-3 (n-3) FAs are important predictors for metabolic syndrome, diabetes, CVD, and CKD risks, and the n-3 index is also a good biomarker for sudden cardiac death in coronary artery disease. Linoleic acid, which is one of the major n-6 FAs reflecting recent dietary FA intake, may predict CVD risk and mortality in the general population and patients with CKD. Monounsaturated FAs (MUFAs) are also related to diabetes or diabetic nephropathy. Oleic acid, a major MUFA, is an emerging marker that is related to acute coronary syndrome, low glomerular filtration rate, and vascular calcification in patients with CKD, and can be modified by n-3 FA supplementation. Saturated FAs, trans-FAs, and FA desaturation/elongation are associated with CVD risk; however, few studies have been conducted on patients with CKD. In summary, blood or erythrocyte membrane FA measurements are important for CVD and CKD risk prediction and management. Further studies are needed to elucidate the FAs for their risk predictions. View Full-Text
Keywords: fatty acid; cardiovascular disease; chronic kidney disease; saturated fatty acid; monounsaturated fatty acid; omega-3 fatty acid; omega-6 fatty acid; trans-fatty acid fatty acid; cardiovascular disease; chronic kidney disease; saturated fatty acid; monounsaturated fatty acid; omega-3 fatty acid; omega-6 fatty acid; trans-fatty acid
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Kim, O.Y.; Lee, S.M.; An, W.S. Impact of Blood or Erythrocyte Membrane Fatty Acids for Disease Risk Prediction: Focusing on Cardiovascular Disease and Chronic Kidney Disease. Nutrients 2018, 10, 1454.

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