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Article

Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models

1
Graduate School of Regional Innovation Studies, Mie University, Tsu, Mie 514-8507, Japan
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Mie University Zebrafish Drug Screening Center, Tsu, Mie 514-8507, Japan
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Department of Integrative Pharmacology, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan
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Department of Bioinformatics, Mie University Advanced Science Research Promotion Center, Tsu, Mie 514-8507, Japan
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Konan Chemical Manufacturing Co., Ltd., Yokkaichi, Mie 510-0103, Japan
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College of Business, Oregon State University, Corvallis, OR 97331, USA
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Coastal Oregon Marine Experiment Station and Department of Fisheries and Wildlife, Hatfield Marine Science Center, College of Agricultural Sciences, Oregon State University, Corvallis, OR 97331, USA
*
Author to whom correspondence should be addressed.
Equal contribution to this work.
Nutrients 2018, 10(10), 1401; https://doi.org/10.3390/nu10101401
Received: 27 August 2018 / Revised: 26 September 2018 / Accepted: 28 September 2018 / Published: 2 October 2018
(1) Background: The red seaweed Palmaria mollis (PM), which has a bacon-like taste, is increasingly being included in Western diets. In this study, we evaluate anti-obesity effects of PM using diet-induced obese (DIO) zebrafish and mice models. (2) Methods: We fed PM-containing feed to DIO-zebrafish and mice, and evaluated the anti-obesity effects We also analyzed gene expression changes in their liver and visceral adipose tissues (VAT). (3) Results: PM ameliorated several anti-obesity traits in both animals, including dyslipidaemia, hepatic steatosis, and visceral adiposity. In liver tissues of DIO-zebrafish and mice, PM upregulated gene expressions involved in peroxisome proliferator-activated receptor alpha (PPARA) pathways, and downregulated peroxisome proliferator-activated receptor gamma (PPARG) pathways, suggesting that the lipid-lowering effect of PM might be caused by activation of beta-oxidation and inhibition of lipogenesis. In VAT, PM downregulated genes involved in early and late adipocyte differentiation in zebrafish, but not in mice. (4) Conclusions: We have demonstrated that PM can prevent hepatic steatosis and visceral adiposity for the first time. Dietary supplementation of PM as a functional food may be suitable for obesity prevention and reduction in the prevalence of obesity-related diseases. View Full-Text
Keywords: metabolic syndrome; animal model; comparative genomics; adipogenesis metabolic syndrome; animal model; comparative genomics; adipogenesis
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MDPI and ACS Style

Nakayama, H.; Shimada, Y.; Zang, L.; Terasawa, M.; Nishiura, K.; Matsuda, K.; Toombs, C.; Langdon, C.; Nishimura, N. Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models. Nutrients 2018, 10, 1401. https://doi.org/10.3390/nu10101401

AMA Style

Nakayama H, Shimada Y, Zang L, Terasawa M, Nishiura K, Matsuda K, Toombs C, Langdon C, Nishimura N. Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models. Nutrients. 2018; 10(10):1401. https://doi.org/10.3390/nu10101401

Chicago/Turabian Style

Nakayama, Hiroko, Yasuhito Shimada, Liqing Zang, Masahiro Terasawa, Kaoru Nishiura, Koichi Matsuda, Charles Toombs, Chris Langdon, and Norihiro Nishimura. 2018. "Novel Anti-Obesity Properties of Palmaria mollis in Zebrafish and Mouse Models" Nutrients 10, no. 10: 1401. https://doi.org/10.3390/nu10101401

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