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DKB114, A Mixture of Chrysanthemum Indicum Linne Flower and Cinnamomum Cassia (L.) J. Presl Bark Extracts, Improves Hyperuricemia through Inhibition of Xanthine Oxidase Activity and Increasing Urine Excretion

1
Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Dajeon 34054, Korea
2
Institute of Traditional Medicine and Bioscience, Daejeon University, 62 Daehak-ro, Dong-gu, Daejeon 34520, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2018, 10(10), 1381; https://doi.org/10.3390/nu10101381
Received: 30 August 2018 / Revised: 18 September 2018 / Accepted: 25 September 2018 / Published: 28 September 2018
Chrysanthemum indicum Linne flower (CF) and Cinnamomum cassia (L.) J. Presl bark (CB) extracts have been used as the main ingredients in several prescriptions to treat the hyperuricemia and gout in traditional medicine. In the present study, we investigated the antihyperuricemic effects of DKB114, a CF, and CB mixture, and the underlying mechanisms in vitro and in vivo. DKB114 markedly reduced serum uric acid levels in normal rats and rats with PO-induced hyperuricemia, while increasing renal uric acid excretion. Furthermore, it inhibited the activity of xanthine oxidase (XOD) in vitro and in the liver in addition to reducing hepatic uric acid production. DKB114 decreased cellular uric acid uptake in oocytes and HEK293 cells expressing human urate transporter (hURAT)1 and decreased the protein expression levels of urate transporters, URAT1, and glucose transporter, GLUT9, associated with the reabsorption of uric acid in the kidney. DKB114 exerts antihyperuricemic effects and uricosuric effects, which are accompanied, partially, by a reduction in the production of uric acid and promotion of uric acid excretion via the inhibition of XOD activity and reabsorption of uric acid. Therefore, it may have potential as a treatment for hyperuricemia and gout. View Full-Text
Keywords: Chrysanthemum indicum Linne flower; Cinnamomum cassia (L.) J. Presl bark; hyperuricemia; xanthine oxidase; urate transporters Chrysanthemum indicum Linne flower; Cinnamomum cassia (L.) J. Presl bark; hyperuricemia; xanthine oxidase; urate transporters
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MDPI and ACS Style

Lee, Y.-S.; Kim, S.-H.; Yuk, H.J.; Kim, D.-S. DKB114, A Mixture of Chrysanthemum Indicum Linne Flower and Cinnamomum Cassia (L.) J. Presl Bark Extracts, Improves Hyperuricemia through Inhibition of Xanthine Oxidase Activity and Increasing Urine Excretion. Nutrients 2018, 10, 1381. https://doi.org/10.3390/nu10101381

AMA Style

Lee Y-S, Kim S-H, Yuk HJ, Kim D-S. DKB114, A Mixture of Chrysanthemum Indicum Linne Flower and Cinnamomum Cassia (L.) J. Presl Bark Extracts, Improves Hyperuricemia through Inhibition of Xanthine Oxidase Activity and Increasing Urine Excretion. Nutrients. 2018; 10(10):1381. https://doi.org/10.3390/nu10101381

Chicago/Turabian Style

Lee, Young-Sil, Seung-Hyung Kim, Heung Joo Yuk, and Dong-Seon Kim. 2018. "DKB114, A Mixture of Chrysanthemum Indicum Linne Flower and Cinnamomum Cassia (L.) J. Presl Bark Extracts, Improves Hyperuricemia through Inhibition of Xanthine Oxidase Activity and Increasing Urine Excretion" Nutrients 10, no. 10: 1381. https://doi.org/10.3390/nu10101381

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