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Sustainability
Volume 17
Issue 2
10.3390/su17020719
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Review

Improving Crop Tolerance to Abiotic Stress for Sustainable Agriculture: Progress in Manipulating Ascorbic Acid Metabolism via Genome Editing

by
Ugo Rogo
1,
Ambra Viviani
2,
Claudio Pugliesi
1,*,
Marco Fambrini
1,
Gabriele Usai
1,
Marco Castellacci
1 and
Samuel Simoni
1
1
Department of Agriculture, Food and Environment, University of Pisa, Via del Borghetto, 80, I-56124 Pisa, Italy
2
Department of Agricultural and Food Sciences and Technologies (DISTAL), Alma Mater Studiorum—Università di Bologna, Viale G. Fanin, 44, I-40127 Bologna, Italy
*
Author to whom correspondence should be addressed.
Sustainability 2025, 17(2), 719; https://doi.org/10.3390/su17020719
Submission received: 29 November 2024 / Revised: 9 January 2025 / Accepted: 17 January 2025 / Published: 17 January 2025
(This article belongs to the Special Issue Adaptive Response and Mechanism of Crops to Abiotic Stresses—2nd Edition)
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Abstract

Plants often encounter challenging environmental factors, including intense sunlight, drought, extreme heat, cold temperatures, salinity, excessive metals, and nutrient shortages, which can heavily affect their growth and survival. In this regard, L-ascorbic acid (AsA) is not only an essential nutrient for human health but also plays a significant role in plant responses to environmental stresses, regulating various functions during growth and development, redox signaling, and phytohormone biosynthesis. The growing need to cope with climate change, together with the advancement of CRISPR/Cas9-editing technologies, stimulated new opportunities to enhance AsA biosynthesis to improve crop stress tolerance. In this review, we discuss the biosynthesis and regulation of AsA in abiotic stress response mechanisms. We also explore the latest advancements of CRISPR/Cas9 technologies, their applications, and their challenges as tools for modifying genes associated with AsA metabolism, aiming to develop crops more tolerant and resilient to environmental changes.
Keywords: L-ascorbic acid; abiotic stresses; reactive oxygen species; sustainable technologies and innovations; CRISPR/Cas; plant resilience L-ascorbic acid; abiotic stresses; reactive oxygen species; sustainable technologies and innovations; CRISPR/Cas; plant resilience

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MDPI and ACS Style

Rogo, U.; Viviani, A.; Pugliesi, C.; Fambrini, M.; Usai, G.; Castellacci, M.; Simoni, S. Improving Crop Tolerance to Abiotic Stress for Sustainable Agriculture: Progress in Manipulating Ascorbic Acid Metabolism via Genome Editing. Sustainability 2025, 17, 719. https://doi.org/10.3390/su17020719

AMA Style

Rogo U, Viviani A, Pugliesi C, Fambrini M, Usai G, Castellacci M, Simoni S. Improving Crop Tolerance to Abiotic Stress for Sustainable Agriculture: Progress in Manipulating Ascorbic Acid Metabolism via Genome Editing. Sustainability. 2025; 17(2):719. https://doi.org/10.3390/su17020719

Chicago/Turabian Style

Rogo, Ugo, Ambra Viviani, Claudio Pugliesi, Marco Fambrini, Gabriele Usai, Marco Castellacci, and Samuel Simoni. 2025. "Improving Crop Tolerance to Abiotic Stress for Sustainable Agriculture: Progress in Manipulating Ascorbic Acid Metabolism via Genome Editing" Sustainability 17, no. 2: 719. https://doi.org/10.3390/su17020719

APA Style

Rogo, U., Viviani, A., Pugliesi, C., Fambrini, M., Usai, G., Castellacci, M., & Simoni, S. (2025). Improving Crop Tolerance to Abiotic Stress for Sustainable Agriculture: Progress in Manipulating Ascorbic Acid Metabolism via Genome Editing. Sustainability, 17(2), 719. https://doi.org/10.3390/su17020719

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