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Article

Prostate Magnetic Resonance Imaging Analyses, Clinical Parameters, and Preoperative Nomograms in the Prediction of Extraprostatic Extension

1
Transplantology, General Surgery and Urology Department, Poznan District Hospital, Juraszow 7-19, 60-479 Poznan, Poland
2
Hepatobiliary and General Surgery Department, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Sklodowskiej-Curie 9, 85-094 Bydgoszcz, Poland
3
Department of General Radiology and Neuroradiology, Poznan University of Medical Sciences, Przybyszewskiego 49, 60-355 Poznan, Poland
*
Author to whom correspondence should be addressed.
Clin. Pract. 2021, 11(4), 763-774; https://doi.org/10.3390/clinpract11040091
Received: 25 July 2021 / Revised: 27 August 2021 / Accepted: 30 September 2021 / Published: 9 October 2021
Introduction: Proper planning of laparoscopic radical prostatectomy (RP) in patients with prostate cancer (PCa) is crucial to achieving good oncological results with the possibility of preserving potency and continence. Aim: The aim of this study was to identify the radiological and clinical parameters that can predict the risk of extraprostatic extension (EPE) for a specific site of the prostate. Predictive models and multiparametric magnetic resonance imaging (mpMRI) data from patients qualified for RP were compared. Material and methods: The study included 61 patients who underwent laparoscopic RP. mpMRI preceded transrectal systematic and cognitive fusion biopsy. Martini, Memorial Sloan-Kettering Cancer Center (MSKCC), and Partin Tables nomograms were used to assess the risk of EPE. The area under the curve (AUC) was calculated for the models and compared. Univariate and multivariate logistic regression analyses were used to determine the combination of variables that best predicted EPE risk based on final histopathology. Results: The combination of mpMRI indicating or suspecting EPE (odds ratio (OR) = 7.49 (2.31–24.27), p < 0.001) and PSA ≥ 20 ng/mL (OR = 12.06 (1.1–132.15), p = 0.04) best predicted the risk of EPE for a specific side of the prostate. For the prediction of ipsilateral EPE risk, the AUC for Martini’s nomogram vs. mpMRI was 0.73 (p < 0.001) vs. 0.63 (p = 0.005), respectively (p = 0.131). The assessment of a non-specific site of EPE by MSKCC vs. Partin Tables showed AUC values of 0.71 (p = 0.007) vs. 0.63 (p = 0.074), respectively (p = 0.211). Conclusions: The combined use of mpMRI, the results of the systematic and targeted biopsy, and prostate-specific antigen baseline can effectively predict ipsilateral EPE (pT3 stage). View Full-Text
Keywords: prostate cancer; radical prostatectomy; predictive nomogram; preoperative nomogram; MRI; planning surgery prostate cancer; radical prostatectomy; predictive nomogram; preoperative nomogram; MRI; planning surgery
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MDPI and ACS Style

Majchrzak, N.; Cieśliński, P.; Głyda, M.; Karmelita-Katulska, K. Prostate Magnetic Resonance Imaging Analyses, Clinical Parameters, and Preoperative Nomograms in the Prediction of Extraprostatic Extension. Clin. Pract. 2021, 11, 763-774. https://doi.org/10.3390/clinpract11040091

AMA Style

Majchrzak N, Cieśliński P, Głyda M, Karmelita-Katulska K. Prostate Magnetic Resonance Imaging Analyses, Clinical Parameters, and Preoperative Nomograms in the Prediction of Extraprostatic Extension. Clinics and Practice. 2021; 11(4):763-774. https://doi.org/10.3390/clinpract11040091

Chicago/Turabian Style

Majchrzak, Natalia, Piotr Cieśliński, Maciej Głyda, and Katarzyna Karmelita-Katulska. 2021. "Prostate Magnetic Resonance Imaging Analyses, Clinical Parameters, and Preoperative Nomograms in the Prediction of Extraprostatic Extension" Clinics and Practice 11, no. 4: 763-774. https://doi.org/10.3390/clinpract11040091

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