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The Effect of Ranibizumab Loading Treatment on Vision-Related Quality of Life in Diabetic Macular Edema

1
Faculty of Medicine, Usak University, 64000 Usak, Turkey
2
Tarsus State Hospital, 33460 Mersin, Turkey
3
Faculty of Medicine, Izmir Katip Celebi University, 35620 İzmir, Turkey
*
Author to whom correspondence should be addressed.
This original article was previously presented as an oral presentation at the Turkish Ophthalmological Association 53, National Congress on 6–10 November 2019 in Antalya, Turkey.
Clin. Pract. 2021, 11(3), 659-670; https://doi.org/10.3390/clinpract11030081
Received: 11 July 2021 / Revised: 14 August 2021 / Accepted: 6 September 2021 / Published: 14 September 2021
Aims: To investigate the changes in vision-related quality of life after a loading dose of three consecutive intravitreal ranibizumab (IVR) injections in patients with unilateral diabetic macular edema (DME). Materials and Methods: Fifty-two eyes of 52 patients who received IVR injections in only one eye with DME were included in our study. The following characteristics of the patients were recorded: gender, education status, marital status, work status, presence of chronic disease. The changes in best-corrected visual acuity (BCVA) and central macular thickness (CMT) were evaluated at baseline (before treatment) and 1 month after the third intravitreal injection (after treatment). Patients were administered the Turkish form of the National Eye Institute 25-Item Visual Functions Questionnaire (NEI VFQ-25 TR). The quality of life scores assessed by the NEI VFQ-25 TR, the BCVA, intraocular pressure (IOP), and CMT measurements were compared at baseline (before treatment) and 1 month after the third intravitreal injection (after treatment). Results: We enrolled 52 patients (25 females, 27 males) in our study; mean age was 64.35 ± 9.26 years. After treatment, BCVA improved significantly (p = 0.001), and macular thickness decreased significantly (p < 0.001). All NEI VFQ-25 TR subscale scores were significantly higher after treatment (p < 0.05). However, no significant correlation was found between the change in BCVA and CMT and the change in NEI VFQ-25 TR subscale and composite scores. The increase in near activities scores was significantly higher in males (p = 0.020) and in the retired group (p = 0.022). There were no significant differences in the changes in NEI VFQ-25 TR subscale and composite scores in relation to educational status. Discussion: Significant improvements in BCVA, macular edema, and vision-related quality of life were found in DME patients who received IVR injections with a loading dose, as shown by the NEI VFQ-25 TR. Interestingly, a significant improvement in quality of life was observed even though the patients could see well with the fellow eye. In conclusion, the NEI VFQ-25 TR is a useful scale to evaluate the changes in visual function and psychosocial characteristics of DME patients after treatment. View Full-Text
Keywords: diabetic macular edema; best-corrected visual acuity; intravitreal ranibizumab; central macular thickness; national eye institute 25-item visual function questionnaire diabetic macular edema; best-corrected visual acuity; intravitreal ranibizumab; central macular thickness; national eye institute 25-item visual function questionnaire
MDPI and ACS Style

Daldal, H.; Turkyilmaz, M.; Balikoglu Yilmaz, M.; Berberoglu, U. The Effect of Ranibizumab Loading Treatment on Vision-Related Quality of Life in Diabetic Macular Edema. Clin. Pract. 2021, 11, 659-670. https://doi.org/10.3390/clinpract11030081

AMA Style

Daldal H, Turkyilmaz M, Balikoglu Yilmaz M, Berberoglu U. The Effect of Ranibizumab Loading Treatment on Vision-Related Quality of Life in Diabetic Macular Edema. Clinics and Practice. 2021; 11(3):659-670. https://doi.org/10.3390/clinpract11030081

Chicago/Turabian Style

Daldal, Hatice, Mustafa Turkyilmaz, Melike Balikoglu Yilmaz, and Ufuk Berberoglu. 2021. "The Effect of Ranibizumab Loading Treatment on Vision-Related Quality of Life in Diabetic Macular Edema" Clinics and Practice 11, no. 3: 659-670. https://doi.org/10.3390/clinpract11030081

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