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Article

Endoscopic and Histopathological Findings of the Esophagus, Stomach, and Duodenum in Patients with Crohn’s Disease from a Reference Center in Bahia, Brazil

1
Medicine and Health Science Postgraduate Program, Federal University of Bahia, Salvador 40026-010, Brazil
2
Pathology Laboratory, Gonçalo Moniz Institute Fiocruz Bahia, Salvador 40296-710, Brazil
3
Gastroenterology Unit, Hospital Geral Roberto Santos, Salvador 45675-000, Brazil
4
Department of Life Sciences, Universidade do Estado da Bahia, Salvador 41195-001, Brazil
5
Medical School, Centro Universitário UniFTC, Salvador 41741-590, Brazil
6
Department of Sciences of Nutrition, School of Nutrition, Federal University of Bahia, Salvador 41195-00, Brazil
*
Author to whom correspondence should be addressed.
Clin. Pract. 2021, 11(2), 374-385; https://doi.org/10.3390/clinpract11020052
Received: 30 March 2021 / Revised: 12 May 2021 / Accepted: 9 June 2021 / Published: 15 June 2021
(1) The aim of the present study was to describe the endoscopic and histopathological findings in the esophagus, stomach, and duodenum in patients with Crohn’s disease. (2) Methods: This was a cross-sectional study that included patients receiving treatment from the inflammatory bowel disease outpatient clinic. Esophagogastroduodenoscopies with biopsies of the stomach and proximal duodenum were performed. Presence of Helicobacter pylori bacteria was assessed by Giemsa staining. (3) Results: We included 58 patients. Erosive esophagitis was identified in 25 patients (43.1%), gastritis was diagnosed in 32 patients (55.2%) and erosive duodenitis was found in eight (13.8%). The most frequent histopathological finding in the H. pylori-positive group was increased inflammatory activity in the gastric body and antrum, with a predominance of mononuclear and polymorphonuclear cells. In turn, the most frequent finding in the H. pylori-negative group was chronic inflammation with predominance of mononuclear cells. Focally enhanced gastritis was identified in four patients (6.9%), all of whom were negative for H. pylori. Granulomas were not observed. H. pylori infection was present in 19 patients (32.8%). (4) Conclusions: Nonspecific endoscopic and histological findings were frequent in patients with Crohn’s disease. Focally enhanced gastritis was uncommon and observed only in H. pylori-negative patients. The time from the diagnosis, patient age, and therapy in use may have influenced the nondetection of epithelioid granuloma. View Full-Text
Keywords: Crohn’s disease; gastritis; enhanced focally gastritis; granuloma; Helicobacter pylori Crohn’s disease; gastritis; enhanced focally gastritis; granuloma; Helicobacter pylori
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MDPI and ACS Style

Pimentel, A.M.; Freitas, L.A.R.d.; Cruz, R.d.C.R.; Silva, I.N.d.N.; Andrade, L.D.; Marques, P.N.; Braga, J.C.; Fortes, F.M.L.; Brito, K.R.M.; Fontes, J.A.M.; Almeida, N.P.; Surlo, V.C.; Rocha, R.; Lyra, A.C.; Santana, G.O. Endoscopic and Histopathological Findings of the Esophagus, Stomach, and Duodenum in Patients with Crohn’s Disease from a Reference Center in Bahia, Brazil. Clin. Pract. 2021, 11, 374-385. https://doi.org/10.3390/clinpract11020052

AMA Style

Pimentel AM, Freitas LARd, Cruz RdCR, Silva INdN, Andrade LD, Marques PN, Braga JC, Fortes FML, Brito KRM, Fontes JAM, Almeida NP, Surlo VC, Rocha R, Lyra AC, Santana GO. Endoscopic and Histopathological Findings of the Esophagus, Stomach, and Duodenum in Patients with Crohn’s Disease from a Reference Center in Bahia, Brazil. Clinics and Practice. 2021; 11(2):374-385. https://doi.org/10.3390/clinpract11020052

Chicago/Turabian Style

Pimentel, Andrea M., Luiz A.R.d. Freitas, Rita d.C.R. Cruz, Isaac N.d.N. Silva, Laíla D. Andrade, Paola N. Marques, Júlia C. Braga, Flora M.L. Fortes, Katia R.M. Brito, Jaciane A.M. Fontes, Neogélia P. Almeida, Valdiana C. Surlo, Raquel Rocha, André C. Lyra, and Genoile O. Santana 2021. "Endoscopic and Histopathological Findings of the Esophagus, Stomach, and Duodenum in Patients with Crohn’s Disease from a Reference Center in Bahia, Brazil" Clinics and Practice 11, no. 2: 374-385. https://doi.org/10.3390/clinpract11020052

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