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Open AccessCase Report

A Case of Thrombotic Thrombocytopenic Purpura without Pathognomonic Schistocytes

by 1,* and 2,3
1
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
2
Department of Hematology and Oncology, Alta Bates Summit Medical Center, Summit Campus, Oakland, CA 94609, USA
3
Medical Oncology and Hematology, Epic Care, Emeryville, CA 94608, USA
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Aricò
Clin. Pract. 2021, 11(2), 223-227; https://doi.org/10.3390/clinpract11020033
Received: 7 December 2020 / Revised: 5 April 2021 / Accepted: 8 April 2021 / Published: 13 April 2021
Patients diagnosed with thrombotic thrombocytopenic purpura (TTP) typically present with microangiopathic hemolytic anemia (MAHA) and thrombocytopenia; these two clinical manifestations were often believed to be essential indicators of TTP. However, such indicators are not always present in every case. Here, we present a patient affected by TTP but showing no distinctive schistocytes on blood smear review. TTP was diagnosed through a critically low level of a disintegrin and metalloproteinase with thrombospondin type 1 motif, member 13 (ADAMTS13) activity. Awareness of such an atypical presentation of TTP is essential for timely treatment to prevent serious and even fatal outcomes for patients. View Full-Text
Keywords: thrombotic thrombocytopenic purpura; blood smear; schistocytes thrombotic thrombocytopenic purpura; blood smear; schistocytes
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MDPI and ACS Style

Yu, K.; Yan, M. A Case of Thrombotic Thrombocytopenic Purpura without Pathognomonic Schistocytes. Clin. Pract. 2021, 11, 223-227. https://doi.org/10.3390/clinpract11020033

AMA Style

Yu K, Yan M. A Case of Thrombotic Thrombocytopenic Purpura without Pathognomonic Schistocytes. Clinics and Practice. 2021; 11(2):223-227. https://doi.org/10.3390/clinpract11020033

Chicago/Turabian Style

Yu, Kevin; Yan, Min. 2021. "A Case of Thrombotic Thrombocytopenic Purpura without Pathognomonic Schistocytes" Clin. Pract. 11, no. 2: 223-227. https://doi.org/10.3390/clinpract11020033

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