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Psilocybin for Treating Psychiatric Disorders: A Psychonaut Legend or a Promising Therapeutic Perspective?

1
Department of Addiction, ASL CN2, Corso Coppino 46, 12051 Alba, CN, Italy
2
Department of Mental Health, ASL CN1, Via Torino 70/B, 12037 Saluzzo, CN, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Wen-Tsong Hsieh
J. Xenobiot. 2022, 12(1), 41-52; https://doi.org/10.3390/jox12010004
Received: 25 June 2021 / Revised: 26 October 2021 / Accepted: 24 November 2021 / Published: 7 February 2022
Psychedelics extracted from plants have been used in religious, spiritual, and mystic practices for millennia. In 1957, Dr. Hofmann identified and synthesized the prodrug psilocybin, a substance present in more than 200 species of psychedelic mushrooms. Although there were limitations related to the scientific design of many studies, clinical observations performed during the 1950s and 1960s showed a potential therapeutic effect of psilocybin for patients affected by depressive symptoms, anxiety, and conversion disorder. Psilocybin was classed as a schedule I substance in 1970, but the fascination with psychedelics has remained almost unchanged over time, promoting a new scientific interest starting in the 1990s. Recent studies have provided further evidence supporting the suggestive hypothesis of the therapeutic use of psilocybin for treating various psychiatric disorders, including pathological anxiety, mood depressive disorder, and addiction. View Full-Text
Keywords: psilocybin; psilocin; psychedelics; magic mushrooms psilocybin; psilocin; psychedelics; magic mushrooms
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MDPI and ACS Style

Coppola, M.; Bevione, F.; Mondola, R. Psilocybin for Treating Psychiatric Disorders: A Psychonaut Legend or a Promising Therapeutic Perspective? J. Xenobiot. 2022, 12, 41-52. https://doi.org/10.3390/jox12010004

AMA Style

Coppola M, Bevione F, Mondola R. Psilocybin for Treating Psychiatric Disorders: A Psychonaut Legend or a Promising Therapeutic Perspective? Journal of Xenobiotics. 2022; 12(1):41-52. https://doi.org/10.3390/jox12010004

Chicago/Turabian Style

Coppola, Maurizio, Francesco Bevione, and Raffaella Mondola. 2022. "Psilocybin for Treating Psychiatric Disorders: A Psychonaut Legend or a Promising Therapeutic Perspective?" Journal of Xenobiotics 12, no. 1: 41-52. https://doi.org/10.3390/jox12010004

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