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Thalassemia Reports
Volume 6
Issue 1
10.4081/thal.2016.4939
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Article

Carotid Intima-Media Thickness and Oxidative Stress Markers for Assessment of Atherosclerosis in Children with ? Thalassemia Major

by
Geetanjali Jindal
1,*,
Prashant Chavan
1,
Ravinder Kaur
2,
Shivani Jaswal
3,
Kamal Kumar Singhal
1,
Anshu Palta
4 and
Vishal Guglani
1
1
Department of Pediatrics, Government Medical College and Hospital, # 1203, Sector 32-B (GMCH, Doctors’ complex), Chandigarh, India
2
Department of Radiodiagnosis, Government Medical College and Hospital, # 1203, Sector 32-B (GMCH, Doctors’ complex), Chandigarh, India
3
Department of Biochemistry, Government Medical College and Hospital, # 1203, Sector 32-B (GMCH, Doctors’ complex), Chandigarh, India
4
Department of Pathology, Government Medical College and Hospital, # 1203, Sector 32-B (GMCH, Doctors’ complex), Chandigarh, India
*
Author to whom correspondence should be addressed.
Thalass. Rep. 2016, 6(1), 4939; https://doi.org/10.4081/thal.2016.4939
Submission received: 15 January 2015 / Revised: 29 January 2016 / Accepted: 29 March 2016 / Published: 6 May 2016

Abstract

The present study evaluates carotid intimamedia thickness (CIMT) in children with ? thalassemia major to assess atherosclerosis and its relation to the underlying proposed causative mechanisms via lipid peroxidation product malondialdehyde (MDA), oxidized lowdensity lipoproteins (LDL), total antioxidant level, and lipid profile. A cross sectional study was conducted on 62 children (31 cases and 31 controls). CIMT by high resolution ultrasound and biochemical parameters i.e., total cholesterol, triglycerides, high-density lipoproteins, LDL, Oxidized LDL, lipoprotein (a), lipid peroxidation product MDA and total antioxidant were measured in enrolled subjects and compared. In our study, CIMT was significantly increased in ? thalassemia major patients’ as compared to healthy controls. Mean CIMT in cases was 0.69 ± 0.11 mm and in controls 0.51 ± 0.07 mm. Mean oxidized LDL (EU/mL) in cases 39.3 ± 34.4 (range 14.4 to 160) was significantly raised (p = 0.02, t test) as compared to controls 23.9 ± 13.4 (range 12 to 70). In our study we found MDA levels (nmol/mL) to be increased in ? thalassemia patients as compared to controls. Mean MDA was 10.0 ± 3.27 (4.41 to 17.48) in cases while in controls was 6.87 ± 4.55 (1.5 to 17.9). Our study results show CIMT as an early marker of atherogenesis in ? thalassemia major. Oxidative stress markers are also increased in ? thalassemia major patients and lipoprotein (a) shows a positive correlation with CIMT. The present study points towards various atherogenetic mechanisms in ? thalassemia major.
Keywords: ? thalassemia major; carotid intimamedia thickness; oxidative stress markers; atherosclerosis ? thalassemia major; carotid intimamedia thickness; oxidative stress markers; atherosclerosis

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MDPI and ACS Style

Jindal, G.; Chavan, P.; Kaur, R.; Jaswal, S.; Singhal, K.K.; Palta, A.; Guglani, V. Carotid Intima-Media Thickness and Oxidative Stress Markers for Assessment of Atherosclerosis in Children with ? Thalassemia Major. Thalass. Rep. 2016, 6, 4939. https://doi.org/10.4081/thal.2016.4939

AMA Style

Jindal G, Chavan P, Kaur R, Jaswal S, Singhal KK, Palta A, Guglani V. Carotid Intima-Media Thickness and Oxidative Stress Markers for Assessment of Atherosclerosis in Children with ? Thalassemia Major. Thalassemia Reports. 2016; 6(1):4939. https://doi.org/10.4081/thal.2016.4939

Chicago/Turabian Style

Jindal, Geetanjali, Prashant Chavan, Ravinder Kaur, Shivani Jaswal, Kamal Kumar Singhal, Anshu Palta, and Vishal Guglani. 2016. "Carotid Intima-Media Thickness and Oxidative Stress Markers for Assessment of Atherosclerosis in Children with ? Thalassemia Major" Thalassemia Reports 6, no. 1: 4939. https://doi.org/10.4081/thal.2016.4939

APA Style

Jindal, G., Chavan, P., Kaur, R., Jaswal, S., Singhal, K. K., Palta, A., & Guglani, V. (2016). Carotid Intima-Media Thickness and Oxidative Stress Markers for Assessment of Atherosclerosis in Children with ? Thalassemia Major. Thalassemia Reports, 6(1), 4939. https://doi.org/10.4081/thal.2016.4939

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