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Hematology Reports
Volume 5
Issue 4
10.4081/hr.2013.e16
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Biphenotypic Acute Leukemia with t(15;17) Lacking Promyelocytic-Retinoid Acid Receptor α Rearrangement

by
Makoto Saito
1,*,
Koh Izumiyama
1,
Akio Mori
1,
Tatsuro Irie
1,
Masanori Tanaka
1,
Masanobu Morioka
1 and
Manabu Musashi
2
1
Department of Internal Medicine and Hematology, Aiiku Hospital, Chuo-ku, Minami 4 Nishi 25, Sapporo, Japan
2
Department of Internal Medicine, Sapporo Hanazono Hospital, Sapporo, Japan
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2013, 5(4), e16; https://doi.org/10.4081/hr.2013.e16
Submission received: 22 July 2013 / Revised: 4 October 2013 / Accepted: 17 October 2013 / Published: 4 December 2013

Abstract

Biphenotypic acute leukemias (BAL) account for less than 4% of all cases of acute leukemia. Philadelphia chromosome and 11q23 rearrangement are the most frequently found cytogenetic abnormalities. Since t(15;17) is almost always associated with acute promyelocytic leukemia, t(15;17) in BAL cases is extremely uncommon. We report here a rare and instructive case of BAL with t(15;17) and the successful treatment approach adopted. A 55-year old woman was referred to our hospital for an examination of elevated white blood cell (WBC) counts with blasts (WBC 13.4 × 109/L; 76% blasts). The blasts with acute lymphoblastic leukemia (ALL-L2, FAB) morphology coexpressed B-lymphoid and myeloid lineages, and a cytogenetic study revealed 4q21 abnormalities and t(15;17). However, promyelocytic-retinoid acid receptor α rearrangement was not detected by fluorescence in situ hybridization on interphase nuclei. Our patient was treated with chemotherapy for ALL and gemtuzumab ozogamicin without all-trans-retinoic acid, and has remained in hematologic first complete remission for more than 3.7 years.
Keywords: biphenotypic acute leukemias; t(15; 17); PML/RARα rearrangement; chemotherapy for acute lymphoblastic leukemia; gemtuzumab ozogamicin biphenotypic acute leukemias; t(15; 17); PML/RARα rearrangement; chemotherapy for acute lymphoblastic leukemia; gemtuzumab ozogamicin

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MDPI and ACS Style

Saito, M.; Izumiyama, K.; Mori, A.; Irie, T.; Tanaka, M.; Morioka, M.; Musashi, M. Biphenotypic Acute Leukemia with t(15;17) Lacking Promyelocytic-Retinoid Acid Receptor α Rearrangement. Hematol. Rep. 2013, 5, e16. https://doi.org/10.4081/hr.2013.e16

AMA Style

Saito M, Izumiyama K, Mori A, Irie T, Tanaka M, Morioka M, Musashi M. Biphenotypic Acute Leukemia with t(15;17) Lacking Promyelocytic-Retinoid Acid Receptor α Rearrangement. Hematology Reports. 2013; 5(4):e16. https://doi.org/10.4081/hr.2013.e16

Chicago/Turabian Style

Saito, Makoto, Koh Izumiyama, Akio Mori, Tatsuro Irie, Masanori Tanaka, Masanobu Morioka, and Manabu Musashi. 2013. "Biphenotypic Acute Leukemia with t(15;17) Lacking Promyelocytic-Retinoid Acid Receptor α Rearrangement" Hematology Reports 5, no. 4: e16. https://doi.org/10.4081/hr.2013.e16

APA Style

Saito, M., Izumiyama, K., Mori, A., Irie, T., Tanaka, M., Morioka, M., & Musashi, M. (2013). Biphenotypic Acute Leukemia with t(15;17) Lacking Promyelocytic-Retinoid Acid Receptor α Rearrangement. Hematology Reports, 5(4), e16. https://doi.org/10.4081/hr.2013.e16

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