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Hematology Reports
Volume 5
Issue 4
10.4081/hr.2013.e15
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Infection Pattern of Neutropenic Patients in Post-Chemotherapy Phase of Acute Leukemia Treatment

by
Ahmad Ahmadzadeh
1,*,
Mehran Varnasseri
2,
Mohammad Hossein Jalili
3,
Fatemeh Maniavi
4,
Armita Valizadeh
5,
Mojtaba Mahmoodian
6 and
Manouchehr Keyhani
7
1
Reaserch Center of Thalassemia and Hemoglobinopathy, Ahvaz Jundishapur University of Medical Science, Ahvaz 61375-15794, Iran
2
Department of Infectious Disease, Razi Hospital, Ahvaz Jundishapur University of Medical Science, Ahvaz 61375-15794, Iran
3
Department of Medicine, Tehran University of Medical Science, Tehran 14155-6559, Iran
4
Department of Infection Control, Shafa Hospital, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61375-15794, Iran
5
Department of Anatomy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61375-15794, Iran
6
Department of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz 61375-15794, Iran
7
Hematology and Oncology Research Center, Vali Asr Hospital, Tehran University of Medical Science, Tehran 14155-6559, Iran
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2013, 5(4), e15; https://doi.org/10.4081/hr.2013.e15
Submission received: 11 July 2013 / Revised: 8 October 2013 / Accepted: 17 October 2013 / Published: 4 December 2013

Abstract

Neutropenia following chemotherapy regimens in leukemia patients is of major concern since it makes these patients vulnerable to infections. If we can identify which germs are causing these infections, they can be annihilated or, at least, the most appropriate antibiotic therapy can be started immediately, even before we have the results of the culture. This retrospective multi-center study took place in 2012 and included patients with acute leukemia who had already undergone chemotherapy and who had been febrile for at least 16 h. In order to assess the type of infection, different environments were chosen and the results were compared by t-test and χ2 tests. This study took place in four hospitals in Tehran and Ahwaz, Iran. The study population was made up of 89 patients: 37 with acute lymphoblastic leukemia and 52 with acute myeloid leukemia. The results revealed that blood was the most common site of infection. From all our positive cultures, it was seen that 85.4% of them had gram-negative bacteria with a dominance of E. coli of 25.8% over the other colonies. Also, antibiograms revealed the sensitivity of almost all the gram-negatives to amino glycosides. In contrast with most of the literature, in our patients, gram-negatives are the most common cause of infection and, therefore, administering amino glycosides would be the safest antibiotic therapy to prescribe before culture results are available.
Keywords: acute leukemia; infection; antibiogram acute leukemia; infection; antibiogram

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MDPI and ACS Style

Ahmadzadeh, A.; Varnasseri, M.; Jalili, M.H.; Maniavi, F.; Valizadeh, A.; Mahmoodian, M.; Keyhani, M. Infection Pattern of Neutropenic Patients in Post-Chemotherapy Phase of Acute Leukemia Treatment. Hematol. Rep. 2013, 5, e15. https://doi.org/10.4081/hr.2013.e15

AMA Style

Ahmadzadeh A, Varnasseri M, Jalili MH, Maniavi F, Valizadeh A, Mahmoodian M, Keyhani M. Infection Pattern of Neutropenic Patients in Post-Chemotherapy Phase of Acute Leukemia Treatment. Hematology Reports. 2013; 5(4):e15. https://doi.org/10.4081/hr.2013.e15

Chicago/Turabian Style

Ahmadzadeh, Ahmad, Mehran Varnasseri, Mohammad Hossein Jalili, Fatemeh Maniavi, Armita Valizadeh, Mojtaba Mahmoodian, and Manouchehr Keyhani. 2013. "Infection Pattern of Neutropenic Patients in Post-Chemotherapy Phase of Acute Leukemia Treatment" Hematology Reports 5, no. 4: e15. https://doi.org/10.4081/hr.2013.e15

APA Style

Ahmadzadeh, A., Varnasseri, M., Jalili, M. H., Maniavi, F., Valizadeh, A., Mahmoodian, M., & Keyhani, M. (2013). Infection Pattern of Neutropenic Patients in Post-Chemotherapy Phase of Acute Leukemia Treatment. Hematology Reports, 5(4), e15. https://doi.org/10.4081/hr.2013.e15

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