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Hematology Reports
Volume 5
Issue 2
10.4081/hr.2013.e7
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Recurrent Gastrointestinal Hemorrhage in Treatment with Dasatinib in a Patient Showing SMAD4 Mutation with Acute Lymphoblastic Leukemia Philadelphia Positive and Juvenile Polyposis Hereditary Hemorrhagic Telangiectasia Syndrome

by
Chiara Sartor
,
Cristina Papayannidis
,
Maria Chiara Abbenante
,
Ilaria Iacobucci
,
Alessandro Broccoli
,
Claudia Venturi
,
Nicoletta Testoni
,
Anna Ferrari
and
Giovanni Martinelli
*
Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Via Massarenti, 9, 40138 Bologna, Italy
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2013, 5(2), e7; https://doi.org/10.4081/hr.2013.e7
Submission received: 29 March 2013 / Revised: 10 April 2013 / Accepted: 16 April 2013 / Published: 3 July 2013

Abstract

We report a case of a patient affected by juvenile polyposis and hereditary hemorrhagic telangiectasia linked to a SMAD4 mutation who developed acute lymphoblastic leukemia positive for the Philadelphia chromosome translocation and with a complex karyotype. During the treatment with the tyrosine kinase inhibitor dasatinib the patient presented recurrent severe gastrointestinal hemorrhages linked to the genetic background and aggravated by thrombocytopenia.
Keywords: juvenile poyposis; hereditary hemorrhagic telangiectasia; acute lymphoblastic leukemia; SMAD4; Philadelphia chromosome; dasatinib; hemorrhage juvenile poyposis; hereditary hemorrhagic telangiectasia; acute lymphoblastic leukemia; SMAD4; Philadelphia chromosome; dasatinib; hemorrhage

Share and Cite

MDPI and ACS Style

Sartor, C.; Papayannidis, C.; Abbenante, M.C.; Iacobucci, I.; Broccoli, A.; Venturi, C.; Testoni, N.; Ferrari, A.; Martinelli, G. Recurrent Gastrointestinal Hemorrhage in Treatment with Dasatinib in a Patient Showing SMAD4 Mutation with Acute Lymphoblastic Leukemia Philadelphia Positive and Juvenile Polyposis Hereditary Hemorrhagic Telangiectasia Syndrome. Hematol. Rep. 2013, 5, e7. https://doi.org/10.4081/hr.2013.e7

AMA Style

Sartor C, Papayannidis C, Abbenante MC, Iacobucci I, Broccoli A, Venturi C, Testoni N, Ferrari A, Martinelli G. Recurrent Gastrointestinal Hemorrhage in Treatment with Dasatinib in a Patient Showing SMAD4 Mutation with Acute Lymphoblastic Leukemia Philadelphia Positive and Juvenile Polyposis Hereditary Hemorrhagic Telangiectasia Syndrome. Hematology Reports. 2013; 5(2):e7. https://doi.org/10.4081/hr.2013.e7

Chicago/Turabian Style

Sartor, Chiara, Cristina Papayannidis, Maria Chiara Abbenante, Ilaria Iacobucci, Alessandro Broccoli, Claudia Venturi, Nicoletta Testoni, Anna Ferrari, and Giovanni Martinelli. 2013. "Recurrent Gastrointestinal Hemorrhage in Treatment with Dasatinib in a Patient Showing SMAD4 Mutation with Acute Lymphoblastic Leukemia Philadelphia Positive and Juvenile Polyposis Hereditary Hemorrhagic Telangiectasia Syndrome" Hematology Reports 5, no. 2: e7. https://doi.org/10.4081/hr.2013.e7

APA Style

Sartor, C., Papayannidis, C., Abbenante, M. C., Iacobucci, I., Broccoli, A., Venturi, C., Testoni, N., Ferrari, A., & Martinelli, G. (2013). Recurrent Gastrointestinal Hemorrhage in Treatment with Dasatinib in a Patient Showing SMAD4 Mutation with Acute Lymphoblastic Leukemia Philadelphia Positive and Juvenile Polyposis Hereditary Hemorrhagic Telangiectasia Syndrome. Hematology Reports, 5(2), e7. https://doi.org/10.4081/hr.2013.e7

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