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Hematology Reports
Volume 2
Issue 1
10.4081/hr.2010.e11
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

Clinical Case of Acute Myeloblastic Leukemia with t(8;21)(q22;q22) in a Patient with Klinefelter’s Syndrome

by
Vanya Slavcheva
1,*,
Tzvetan Lukanov
2,
Gueorgui Balatsenko
3,
Svetlana Angelova
3,
Antonio Antonov
1,
Lachezar Bogdanov
1 and
Nikolay Tsvetkov
1
1
Hematology Clinic, University Hospital, 8 A G. Kochev, 5800 Pleven, Bulgaria
2
Flow Cytometric Laboratory, University Hospital, 5800 Pleven, Bulgaria
3
Laboratory of Cytogenetic and Molecular Biology, National Hospital of Hematological Disease, 1756 Sofia, Bulgaria
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2010, 2(1), e11; https://doi.org/10.4081/hr.2010.e11
Submission received: 1 December 2010 / Revised: 15 December 2010 / Accepted: 17 December 2010 / Published: 22 December 2010

Abstract

Klinefelter’s syndrome is characterized by abnormal karyotype 47, XXY and a phenotype associated with hypogonadism and gynecomastia. Often the disease can be diagnosed accidentally, when carrying out cytogenetic analysis in cases of a malignant blood disease. We present the clinical case of a patient diagnosed with acute myelomonoblastic leukemia- M4 Eo (AML- M4), where by means of classic cytogenetics a karyotype was found corre-sponding to Klinefelter’s syndrome. Three induction courses of polychemotherapy wermade, which led to remission of the disease, documented both flowcytometrically and cytogenetically.
Keywords: genetics; Klinefelter’s syndrome; leukemia; remission genetics; Klinefelter’s syndrome; leukemia; remission

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MDPI and ACS Style

Slavcheva, V.; Lukanov, T.; Balatsenko, G.; Angelova, S.; Antonov, A.; Bogdanov, L.; Tsvetkov, N. Clinical Case of Acute Myeloblastic Leukemia with t(8;21)(q22;q22) in a Patient with Klinefelter’s Syndrome. Hematol. Rep. 2010, 2, e11. https://doi.org/10.4081/hr.2010.e11

AMA Style

Slavcheva V, Lukanov T, Balatsenko G, Angelova S, Antonov A, Bogdanov L, Tsvetkov N. Clinical Case of Acute Myeloblastic Leukemia with t(8;21)(q22;q22) in a Patient with Klinefelter’s Syndrome. Hematology Reports. 2010; 2(1):e11. https://doi.org/10.4081/hr.2010.e11

Chicago/Turabian Style

Slavcheva, Vanya, Tzvetan Lukanov, Gueorgui Balatsenko, Svetlana Angelova, Antonio Antonov, Lachezar Bogdanov, and Nikolay Tsvetkov. 2010. "Clinical Case of Acute Myeloblastic Leukemia with t(8;21)(q22;q22) in a Patient with Klinefelter’s Syndrome" Hematology Reports 2, no. 1: e11. https://doi.org/10.4081/hr.2010.e11

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