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Hematology Reports
Volume 2
Issue 1
10.4081/hr.2010.e10
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Case Report

Dural MALT Lymphoma with Disseminated Disease

by
Kelly S. Matmati
,
Nabil Matmati
,
Yusuf A. Hannun
,
Zoran Rumboldt
,
Sunil Patel
,
John Lazarchick
,
Robert Stuart
and
Pierre Giglio
*
Medical University of South Carolina, 96 Jonathan Lucas St., Charleston, SC 29425, USA
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2010, 2(1), e10; https://doi.org/10.4081/hr.2010.e10
Submission received: 15 September 2010 / Revised: 30 November 2010 / Accepted: 1 December 2010 / Published: 3 December 2010

Abstract

Central nervous system (CNS) lymphoma involving the dura mater is very rare and histologically is usually a subtype of non-Hodgkin’s lymphoma (NHL) termed mucosa-associated lymphoid tissue (MALT) lymphoma. We present a case of a 46-year old woman with dural MALT lymphoma that was found to also involve a lacrimal gland, inguinal lymph nodes, and bone marrow. Magnetic resonance imaging of the brain showed an extra-axial enhancing mass approximately 6 cm in maximum diameter along the right frontotemporal convexity. Histopathology of the resected dural mass showed MALT lymphoma expressing CD20, CD52, CD19, and CD38. Molecular studies of the B-cell receptor heavy chain demonstrated monoclonality at the involved sites. The patient was treated with four cycles of fludarabine, mitoxantrone, and rituximab with complete remission. She had recurrence in the subcutaneous tissue of the back at 12 months but has remained free of intracranial disease for 31 months. A review of the literature reveals 57 cases of dural MALT lymphoma. Only 4 had extra-CNS involvement at presentation, and only 3 had local recurrence of the dural tumor. Because of the indolent behavior of this tumor, the intracranial portion can be treated conservatively after resection with or without chemotherapy. Deferral of brain radiation can be considered with close clinical and neuroimaging follow up.
Keywords: MALT lymphoma; dural lymphoma; radiation; chemotherapy; meningioma MALT lymphoma; dural lymphoma; radiation; chemotherapy; meningioma

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MDPI and ACS Style

Matmati, K.S.; Matmati, N.; Hannun, Y.A.; Rumboldt, Z.; Patel, S.; Lazarchick, J.; Stuart, R.; Giglio, P. Dural MALT Lymphoma with Disseminated Disease. Hematol. Rep. 2010, 2, e10. https://doi.org/10.4081/hr.2010.e10

AMA Style

Matmati KS, Matmati N, Hannun YA, Rumboldt Z, Patel S, Lazarchick J, Stuart R, Giglio P. Dural MALT Lymphoma with Disseminated Disease. Hematology Reports. 2010; 2(1):e10. https://doi.org/10.4081/hr.2010.e10

Chicago/Turabian Style

Matmati, Kelly S., Nabil Matmati, Yusuf A. Hannun, Zoran Rumboldt, Sunil Patel, John Lazarchick, Robert Stuart, and Pierre Giglio. 2010. "Dural MALT Lymphoma with Disseminated Disease" Hematology Reports 2, no. 1: e10. https://doi.org/10.4081/hr.2010.e10

APA Style

Matmati, K. S., Matmati, N., Hannun, Y. A., Rumboldt, Z., Patel, S., Lazarchick, J., Stuart, R., & Giglio, P. (2010). Dural MALT Lymphoma with Disseminated Disease. Hematology Reports, 2(1), e10. https://doi.org/10.4081/hr.2010.e10

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