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Volume 15
Issue 4
10.3390/hematolrep15040058
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Case Report

Transient Leukemoid Reaction from T-Cell Large Granular Lymphocytes Post Autologous Stem Cell Transplant in a Patient Affected by Hodgkin Lymphoma

by
Andrea Duminuco
1,*,
Marina Parisi
1,
Giulio Antonio Milone
2,
Alessandra Cupri
1,
Salvatore Leotta
1,
Giuseppe A. Palumbo
3,
Nunziatina Laura Parrinello
1,
Grazia Scuderi
1,
Anna Triolo
1 and
Giuseppe Milone
1
1
Hematology Unit and Bone Marrow Transplant, A.O.U. Policlinico “G. Rodolico—San Marco”, 95123 Catania, Italy
2
Division of Hematology with BMT, Istituto Oncologico del Mediterraneo, 95029 Viagrande, Italy
3
Department of Medical, Surgical Sciences and Advanced Technologies, “G.F. Ingrassia”, University of Catania, 95123 Catania, Italy
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2023, 15(4), 555-561; https://doi.org/10.3390/hematolrep15040058
Submission received: 23 March 2023 / Revised: 25 May 2023 / Accepted: 28 September 2023 / Published: 11 October 2023
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Abstract

Monoclonal T-cell lymphocytosis has been reported in patients with concomitant autoimmune diseases, viral infections, or immunodeficiencies. Referred to as T-cell large granular lymphocytic leukemia (T-LGLL), most cases cannot identify the triggering cause. Only small case series have been reported in the literature, and no treatment consensus exists. T-cell lymphocytosis may also appear after the transplant of hematopoietic stem cells or solid organs. Rare cases have been reported in patients undergoing autologous stem cell transplant (ASCT) for hematological diseases (including multiple myeloma or non-Hodgkin’s lymphoma). Here, we describe the singular case of a patient who underwent ASCT for Hodgkin’s lymphoma and displayed the onset of T-LGLL with an uncommonly high number of lymphocytes in peripheral blood and their subsequent spontaneous remission.
Keywords: Hodgkin lymphoma; T-cell large granular lymphocytic leukemia; cytotoxic T-lymphocytes; ASCT; lymphoproliferative disorder Hodgkin lymphoma; T-cell large granular lymphocytic leukemia; cytotoxic T-lymphocytes; ASCT; lymphoproliferative disorder

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MDPI and ACS Style

Duminuco, A.; Parisi, M.; Milone, G.A.; Cupri, A.; Leotta, S.; Palumbo, G.A.; Parrinello, N.L.; Scuderi, G.; Triolo, A.; Milone, G. Transient Leukemoid Reaction from T-Cell Large Granular Lymphocytes Post Autologous Stem Cell Transplant in a Patient Affected by Hodgkin Lymphoma. Hematol. Rep. 2023, 15, 555-561. https://doi.org/10.3390/hematolrep15040058

AMA Style

Duminuco A, Parisi M, Milone GA, Cupri A, Leotta S, Palumbo GA, Parrinello NL, Scuderi G, Triolo A, Milone G. Transient Leukemoid Reaction from T-Cell Large Granular Lymphocytes Post Autologous Stem Cell Transplant in a Patient Affected by Hodgkin Lymphoma. Hematology Reports. 2023; 15(4):555-561. https://doi.org/10.3390/hematolrep15040058

Chicago/Turabian Style

Duminuco, Andrea, Marina Parisi, Giulio Antonio Milone, Alessandra Cupri, Salvatore Leotta, Giuseppe A. Palumbo, Nunziatina Laura Parrinello, Grazia Scuderi, Anna Triolo, and Giuseppe Milone. 2023. "Transient Leukemoid Reaction from T-Cell Large Granular Lymphocytes Post Autologous Stem Cell Transplant in a Patient Affected by Hodgkin Lymphoma" Hematology Reports 15, no. 4: 555-561. https://doi.org/10.3390/hematolrep15040058

APA Style

Duminuco, A., Parisi, M., Milone, G. A., Cupri, A., Leotta, S., Palumbo, G. A., Parrinello, N. L., Scuderi, G., Triolo, A., & Milone, G. (2023). Transient Leukemoid Reaction from T-Cell Large Granular Lymphocytes Post Autologous Stem Cell Transplant in a Patient Affected by Hodgkin Lymphoma. Hematology Reports, 15(4), 555-561. https://doi.org/10.3390/hematolrep15040058

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