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Hematology Reports
Volume 11
Issue 2
10.4081/hr.2019.8100
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Hematology Reports is published by MDPI from Volume 14 Issue 1 (2022). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Case Report

B-Cell Acute Lymphoblastic Leukemia as a Secondary Malignancy Following Diffuse Large B-Cell Lymphoma

by
Daria Gaut
1,
Anthony Bejjani
2,
Joshua Sasine
2 and
Gary Schiller
2,3,*
1
Department of Medicine, University of California, Los Angeles, CA 90095, USA
2
Division of Hematology/Oncology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA
3
Hematological Malignancies/Stem Cell Transplantation Unit, David Geffen School of Medicine at UCLA, 10833 Le Conte Ave, Room 42-121 CHS, Los Angeles, CA 90095, USA
*
Author to whom correspondence should be addressed.
Hematol. Rep. 2019, 11(2), 8100; https://doi.org/10.4081/hr.2019.8100
Submission received: 2 March 2019 / Revised: 29 April 2019 / Accepted: 13 May 2019 / Published: 14 June 2019

Abstract

Secondary acute lymphoblastic leukemia (ALL) is a rare disease that has not been well characterized compared with secondary myelodysplastic syndrome or secondary acute myeloid leukemia. We present a report of two patients who developed ALL following complete remission of diffuse large B-cell lymphoma (DLBCL). The first case is more consistent with a therapy-related ALL as a PCR analysis of bone marrow aspirate revealed a distinct clone and the mixed-lineage leukemia gene rearrangement, commonly associated with exposure to topoisomerase II inhibitors. The second case is more consistent with clonal evolution given positive MYC and BCL2 fusion signals in the original diagnosis of DLBCL and the secondary ALL.
Keywords: acute lymphoblastic leukemia; diffuse large B-cell lymphoma; secondary malignancy; secondary acute lymphoblastic leukemia; therapy-related acute lymphoblastic leukemia acute lymphoblastic leukemia; diffuse large B-cell lymphoma; secondary malignancy; secondary acute lymphoblastic leukemia; therapy-related acute lymphoblastic leukemia

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MDPI and ACS Style

Gaut, D.; Bejjani, A.; Sasine, J.; Schiller, G. B-Cell Acute Lymphoblastic Leukemia as a Secondary Malignancy Following Diffuse Large B-Cell Lymphoma. Hematol. Rep. 2019, 11, 8100. https://doi.org/10.4081/hr.2019.8100

AMA Style

Gaut D, Bejjani A, Sasine J, Schiller G. B-Cell Acute Lymphoblastic Leukemia as a Secondary Malignancy Following Diffuse Large B-Cell Lymphoma. Hematology Reports. 2019; 11(2):8100. https://doi.org/10.4081/hr.2019.8100

Chicago/Turabian Style

Gaut, Daria, Anthony Bejjani, Joshua Sasine, and Gary Schiller. 2019. "B-Cell Acute Lymphoblastic Leukemia as a Secondary Malignancy Following Diffuse Large B-Cell Lymphoma" Hematology Reports 11, no. 2: 8100. https://doi.org/10.4081/hr.2019.8100

APA Style

Gaut, D., Bejjani, A., Sasine, J., & Schiller, G. (2019). B-Cell Acute Lymphoblastic Leukemia as a Secondary Malignancy Following Diffuse Large B-Cell Lymphoma. Hematology Reports, 11(2), 8100. https://doi.org/10.4081/hr.2019.8100

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