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Infectious Disease Reports
Volume 4
Issue 2
10.4081/idr.2012.e28
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Article

Absence of Chronic Hepatitis E in a German Cohort of Common Variable Immunodeficiency Patients

by
Sven Pischke
1,*,
Ruediger Horn-Wichmann
1,
Diana Ernst
2,
Bjoern Georg Meyer
2,
Regina Raupach
1,
Gerrit Ahrenstorf
2,
Reinhold Ernst Schmidt
3,
Michael Peter Manns
1,
Torsten Witte
2 and
Heiner Wedemeyer
1
1
Clinic for Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany
2
Clinic for Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany
*
Author to whom correspondence should be addressed.
Infect. Dis. Rep. 2012, 4(2), e28; https://doi.org/10.4081/idr.2012.e28
Submission received: 10 October 2011 / Revised: 4 March 2012 / Accepted: 10 March 2012 / Published: 8 May 2012

Abstract

Cases of chronic or prolonged hepatitis E virus (HEV) infections have been described in solid organ transplant recipients, HIV infected patients and in patients with malignancies or idiopathic CD4+ T lymphopenia. It is unknown if HEV infection also takes chronic courses in patients with common variable immunodeficiency (CVID). We studied a cohort of 73 CVID patients recruited in a low endemic Central European country. None of the subjects tested positive for HEV RNA or anti-HEV IgG. Immunoglobulin transfusions (n=10) tested negative for HEV RNA but all were anti-HEV positive. To verify that such pooled blood products contain anti-HEV protective antibodies we measured the anti-HEV IgG optical density (OD) values in patients before and after transfusion. Anti-HEV OD values increased after infusion but did not reach the cut-off considered as positive. Thus, chronic HEV infections seem to be rare events in CVID patients in Germany. Commercially available immuno globulin infusions contain anti HEV antibodies and may contribute to protection from HEV infection
Keywords: hepatitis E; common variable immunodeficiency hepatitis E; common variable immunodeficiency

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MDPI and ACS Style

Pischke, S.; Horn-Wichmann, R.; Ernst, D.; Meyer, B.G.; Raupach, R.; Ahrenstorf, G.; Schmidt, R.E.; Manns, M.P.; Witte, T.; Wedemeyer, H. Absence of Chronic Hepatitis E in a German Cohort of Common Variable Immunodeficiency Patients. Infect. Dis. Rep. 2012, 4, e28. https://doi.org/10.4081/idr.2012.e28

AMA Style

Pischke S, Horn-Wichmann R, Ernst D, Meyer BG, Raupach R, Ahrenstorf G, Schmidt RE, Manns MP, Witte T, Wedemeyer H. Absence of Chronic Hepatitis E in a German Cohort of Common Variable Immunodeficiency Patients. Infectious Disease Reports. 2012; 4(2):e28. https://doi.org/10.4081/idr.2012.e28

Chicago/Turabian Style

Pischke, Sven, Ruediger Horn-Wichmann, Diana Ernst, Bjoern Georg Meyer, Regina Raupach, Gerrit Ahrenstorf, Reinhold Ernst Schmidt, Michael Peter Manns, Torsten Witte, and Heiner Wedemeyer. 2012. "Absence of Chronic Hepatitis E in a German Cohort of Common Variable Immunodeficiency Patients" Infectious Disease Reports 4, no. 2: e28. https://doi.org/10.4081/idr.2012.e28

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