An Aminoglycoside-Sparing Regimen with Double Beta-Lactam to Successfully Treat Granulicatella adiacens Prosthetic Aortic Valve Endocarditis—Time to Change Paradigm?
Abstract
:1. Introduction
2. Case Presentation
3. Laboratory Tests
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
List of Abbreviations
NVS | Nutritionally variant streptococci |
IE | Infective endocarditis |
NVE | Native valve endocarditis |
PVE | Prosthetic valve endocarditis |
AHA | American Heart Association |
ESC | European Society of Cardiology |
GL | Guidelines |
PEN | Penicillin |
AMP | Ampicillin |
BRP | Ceftobiprole |
CRO | Ceftriaxone |
AML | Amoxicillin |
CN | Gentamicin |
AG | Aminoglycoside |
PBPs | Penicillin-binding proteins |
PM | Pacemaker |
ED | Emergency department |
CRP | C-reactive protein |
CT | Computed tomography |
TTE | Transthoracic echocardiography |
MIC | Minimum inhibitory concentration |
MBC | Minimum bactericidal concentration |
MBIC | Minimum biofilm inhibitory concentration |
BMD | Broth micro-dilution |
FIC index | Fractional inhibitory concentration index |
AST | Antimicrobial susceptibility testing |
EFIE | Enterococcus faecalis infective endocarditis |
CMHA | Chocolate Mueller Hinton Agar |
References
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PEN | AMP | AML | BPR | CPT | CRO | CTX | IMI | LNZ | CN | STR | TEI | VAN | DAP | TGC | DAL | |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
NS | NS | S | NA | NA | R | R | S | NA | NA | NA | NA | S | NA | NA | NA | |
Granulicatella | 0.5 | 0.5 | 0.125 | 0.19 | 2 | 32 | 8 | 0.25 | 2 | 4 | 1 | 1 | 1 | 4 * | 0.094 | 0.125 |
DRUG A | DRUG B | MIC Drug A | MIC Drug B | MIC Drug A in Combination | MIC Drug B in Combination | FIC Drug A | FIC Drug B | FIC Index | INTERPRETATION |
---|---|---|---|---|---|---|---|---|---|
AMP 1× | BPR 1× | 0.5 | 0.19 | 0.125 | 0.047 | 0.25 | 0.247 | 0.49 | SYN |
AMP 1× | BPR 2× | 0.5 | 0.38 | 0.125 | 0.023 | 0.25 | 0.06 | 0.31 | SYN |
AMP 1× | CRO 1× | 0.5 | 32 | 0.094 | 2 | 0.188 | 0.062 | 0.25 | SYN |
AMP 1× | CRO 2× | 0.5 | 64 | 0.047 | 8 | 0.094 | 0.125 | 0.21 | SYN |
AMP 1× | CN 1× | 0.5 | 4 | 0.25 | 3 | 0.5 | 0.75 | 1.25 | IND |
AMP 2× | CN 1× | 1 | 4 | 0.25 | 0.75 | 0.25 | 0.188 | 0.4 | SYN |
BPR 1× | CN 1× | 0.19 | 4 | 0.125 | 3 | 0.658 | 0.75 | 1.4 | IND |
BPR 2× | CN 1× | 0.38 | 4 | 0.094 | 1 | 0.247 | 0.25 | 0.4 | SYN |
CRO 1× | CN 1× | 32 | 4 | 16 | 2 | 0.5 | 0.5 | 1 | ADD |
CRO 2× | CN 1× | 64 | 4 | 4 | 0.75 | 0.0625 | 0.187 | 0.25 | SYN |
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Pagotto, A.; Campanile, F.; Conti, P.; Prataviera, F.; Della Siega, P.; Flammini, S.; Giuliano, S.; Martini, L.; Pecori, D.; Sartor, A.; et al. An Aminoglycoside-Sparing Regimen with Double Beta-Lactam to Successfully Treat Granulicatella adiacens Prosthetic Aortic Valve Endocarditis—Time to Change Paradigm? Infect. Dis. Rep. 2024, 16, 249-259. https://doi.org/10.3390/idr16020020
Pagotto A, Campanile F, Conti P, Prataviera F, Della Siega P, Flammini S, Giuliano S, Martini L, Pecori D, Sartor A, et al. An Aminoglycoside-Sparing Regimen with Double Beta-Lactam to Successfully Treat Granulicatella adiacens Prosthetic Aortic Valve Endocarditis—Time to Change Paradigm? Infectious Disease Reports. 2024; 16(2):249-259. https://doi.org/10.3390/idr16020020
Chicago/Turabian StylePagotto, Alberto, Floriana Campanile, Paola Conti, Francesca Prataviera, Paola Della Siega, Sarah Flammini, Simone Giuliano, Luca Martini, Davide Pecori, Assunta Sartor, and et al. 2024. "An Aminoglycoside-Sparing Regimen with Double Beta-Lactam to Successfully Treat Granulicatella adiacens Prosthetic Aortic Valve Endocarditis—Time to Change Paradigm?" Infectious Disease Reports 16, no. 2: 249-259. https://doi.org/10.3390/idr16020020
APA StylePagotto, A., Campanile, F., Conti, P., Prataviera, F., Della Siega, P., Flammini, S., Giuliano, S., Martini, L., Pecori, D., Sartor, A., Screm, M., Semenzin, T., & Tascini, C. (2024). An Aminoglycoside-Sparing Regimen with Double Beta-Lactam to Successfully Treat Granulicatella adiacens Prosthetic Aortic Valve Endocarditis—Time to Change Paradigm? Infectious Disease Reports, 16(2), 249-259. https://doi.org/10.3390/idr16020020