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Infectious Disease Reports
Volume 12
Issue s1
10.4081/idr.2020.8726
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Infectious Disease Reports is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Article

Expression of Fibroblast Cells after Extraction of Wistar Rat Teeth after Topical Application of Okra Fruit (Abelmoschus esculentus) Gel

by
Muhammad Luthfi
*,
Wisnu Setyari Juliastuti
,
Yuniar Aliyah Risky
,
Elvina Hasna Wijayanti
,
Aisyah Ekasari Rachmawati
and
Nidya Pramesti Olifia Asyhari
Department of Oral Biology, Faculty of Dental Medicine, Airlangga University, Surabaya, Indonesia
*
Author to whom correspondence should be addressed.
Infect. Dis. Rep. 2020, 12(s1), 8726; https://doi.org/10.4081/idr.2020.8726
Submission received: 17 February 2020 / Revised: 26 June 2020 / Accepted: 1 July 2020 / Published: 6 July 2020

Abstract

Background: Tooth extraction is a dental procedure for removing a teeth from the alveolar bone socket. The tooth extraction process causes damage to hard tissue and soft tissue, so the body will respond physiologically to heal the wound. The wound healing process is divided into several phases, one of which is the proliferation phase of fibroblasts, which is one of the most important phases in the process of wound healing. Okra fruit contains saponins, tannins, flavonoids and alkaloids that have anti-inflammatory, antibacterial, antioxidant effects, and can stimulate angiogenesis so to accelerate the process of wound healing. Objective: to prove that the administration of okra fruit extract can accelerate the process of wound healing after extraction in the teeth of Wistar rats through increased expression of fibroblast cells. Methods: 18 Wistar rats were divided into 2 groups; control group and treatment group. The treatment group received a 30% okra fruit extract. The number of fibroblasts was calculated statistically using One Way ANOVA and Tukey HSD. Results: The results showed that the expression of control group fibroblast cells on day 3 (19.00 ± 2.0), day 5 (21.67 ± 2.08), day 7 (24.00 ± 2.00), whereas in the treatment group on day 3 (24.00 ± 1.00), day 5 (29.00± 2.00), day 7 (30.00 ± 1.53). Anova test between groups showed a significant difference with P-value 0.006. Conclusion: 30% okra fruit extract can increase fibroblast expression in wound healing process after extraction of Wistar rat teeth.
Keywords: tooth extraction; wound healing; fibroblasts; okra fruit tooth extraction; wound healing; fibroblasts; okra fruit

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MDPI and ACS Style

Luthfi, M.; Juliastuti, W.S.; Risky, Y.A.; Wijayanti, E.H.; Rachmawati, A.E.; Asyhari, N.P.O. Expression of Fibroblast Cells after Extraction of Wistar Rat Teeth after Topical Application of Okra Fruit (Abelmoschus esculentus) Gel. Infect. Dis. Rep. 2020, 12, 8726. https://doi.org/10.4081/idr.2020.8726

AMA Style

Luthfi M, Juliastuti WS, Risky YA, Wijayanti EH, Rachmawati AE, Asyhari NPO. Expression of Fibroblast Cells after Extraction of Wistar Rat Teeth after Topical Application of Okra Fruit (Abelmoschus esculentus) Gel. Infectious Disease Reports. 2020; 12(s1):8726. https://doi.org/10.4081/idr.2020.8726

Chicago/Turabian Style

Luthfi, Muhammad, Wisnu Setyari Juliastuti, Yuniar Aliyah Risky, Elvina Hasna Wijayanti, Aisyah Ekasari Rachmawati, and Nidya Pramesti Olifia Asyhari. 2020. "Expression of Fibroblast Cells after Extraction of Wistar Rat Teeth after Topical Application of Okra Fruit (Abelmoschus esculentus) Gel" Infectious Disease Reports 12, no. s1: 8726. https://doi.org/10.4081/idr.2020.8726

APA Style

Luthfi, M., Juliastuti, W. S., Risky, Y. A., Wijayanti, E. H., Rachmawati, A. E., & Asyhari, N. P. O. (2020). Expression of Fibroblast Cells after Extraction of Wistar Rat Teeth after Topical Application of Okra Fruit (Abelmoschus esculentus) Gel. Infectious Disease Reports, 12(s1), 8726. https://doi.org/10.4081/idr.2020.8726

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