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Neurology International
Volume 9
Issue 3
10.4081/ni.2017.7276
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Neurology International is published by MDPI from Volume 12 Issue 3 (2020). Previous articles were published by another publisher in Open Access under a CC-BY licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with PAGEPress.
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Brief Report

Body Mass Index and Severity of Parkinsonism in Multiple System Atrophy

by
Ai Suzuki
,
Hitoshi Mochizuki
*,
Yuka Ebihara
,
Kazutaka Shiomi
and
Masamitsu Nakazato
Division of Neurology, Respirology, Endocrinology and Metabolism, Department of Internal Medicine, University of Miyazaki, Miyazaki, Japan
*
Author to whom correspondence should be addressed.
Neurol. Int. 2017, 9(3), 7276; https://doi.org/10.4081/ni.2017.7276
Submission received: 22 June 2017 / Revised: 3 August 2017 / Accepted: 3 August 2017 / Published: 28 September 2017

Abstract

Patients with neurodegenerative disorders lose body weight as their diseases progress. In Parkinson’s disease (PD), however, autonomic dysfunction is associated with increased body mass index (BMI). We investigated the correlation between BMI, clinical features, and autonomic dysfunction in patients with multiple system atrophy with predominant parkinsonism (MSAP). BMI, clinical features, cardiac 123Imetaiodobenzylguanidine scintigraphy (MIBG), Hoehn and Yahr (H-Y) stage, and the coefficient of variation of the R-R interval (CVRR) were analyzed in 50 patients with MSA-P. BMI showed no significant correlation with MIBG parameters or CVRR. On the other hand, the H-Y stage was significantly negatively correlated with BMI. Higher H-Y stage indicates a more severe neuromuscular state in MSA-P and is considered to be related to higher energy expenditure and decrease of BMI. Patients with MSA-P lose weight as the disease progresses. This is the first report indicating a significant correlation between disease severity and BMI decrease in MSA.
Keywords: Multiple system atrophy; Body mass index; Cardiac 123I-metaiodobenzylguanidine scintigraphy; Coefficient of variation of the R-R interval Multiple system atrophy; Body mass index; Cardiac 123I-metaiodobenzylguanidine scintigraphy; Coefficient of variation of the R-R interval

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MDPI and ACS Style

Suzuki, A.; Mochizuki, H.; Ebihara, Y.; Shiomi, K.; Nakazato, M. Body Mass Index and Severity of Parkinsonism in Multiple System Atrophy. Neurol. Int. 2017, 9, 7276. https://doi.org/10.4081/ni.2017.7276

AMA Style

Suzuki A, Mochizuki H, Ebihara Y, Shiomi K, Nakazato M. Body Mass Index and Severity of Parkinsonism in Multiple System Atrophy. Neurology International. 2017; 9(3):7276. https://doi.org/10.4081/ni.2017.7276

Chicago/Turabian Style

Suzuki, Ai, Hitoshi Mochizuki, Yuka Ebihara, Kazutaka Shiomi, and Masamitsu Nakazato. 2017. "Body Mass Index and Severity of Parkinsonism in Multiple System Atrophy" Neurology International 9, no. 3: 7276. https://doi.org/10.4081/ni.2017.7276

APA Style

Suzuki, A., Mochizuki, H., Ebihara, Y., Shiomi, K., & Nakazato, M. (2017). Body Mass Index and Severity of Parkinsonism in Multiple System Atrophy. Neurology International, 9(3), 7276. https://doi.org/10.4081/ni.2017.7276

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