This is an early access version, the complete PDF, HTML, and XML versions will be available soon.
Open AccessSystematic Review
MicroRNA and DNA Methylation Adaptation Mechanism to Endurance Training in Cardiovascular Disease: A Systematic Review
1
Department of Health, LUNEX University of Applied Sciences, 50, Avenue du Parc des Sports, 4671 Differdange, Luxembourg
2
Department of Gymnastics and Health, Universidade Federal de Pelotas (Federal University of Pelotas), Pelotas 96010-610, Brazil
3
Luxembourg Health & Sport Sciences Research Institute A.s.b.l., 50, Avenue du Parc des Sports, 4671 Differdange, Luxembourg
*
Author to whom correspondence should be addressed.
Cardiogenetics 2025, 15(4), 28; https://doi.org/10.3390/cardiogenetics15040028 (registering DOI)
Submission received: 8 August 2025
/
Revised: 27 September 2025
/
Accepted: 28 September 2025
/
Published: 11 October 2025
Abstract
Background: Regular endurance training induces physiological changes in cardiac structure and function. The precise epigenetic mechanisms by which cardiovascular adaptations are mediated are still unclear. This review seeks to clarify the role of epigenetic regulation in exercise-induced cardiovascular adaptation. Methods: This systematic review was conducted in accordance with the PRISMA guidelines up to 30 April 2025, using the databases PubMed, VHL, and LILACS Plus. Studies were included if they focused on microRNA expression and DNA methylation in individuals with cardiovascular disease who underwent endurance training. Results: Six articles, including 384 participants with heart failure, coronary artery disease, and hypertension, were included in the final analysis. Changes in DNA methylation and microRNA expression of specific genes involved in cardiovascular structural and functional adaptation were observed. Significant improvements were found in body composition, VO2peak, systolic and diastolic blood pressure, and left ventricular function and structure. Conclusions: Endurance training has a positive impact on epigenetic mechanisms related to cardiovascular structural and functional adaptation. A clear causal link between epigenetic modifications and clinical outcomes remains to be established.
Share and Cite
MDPI and ACS Style
Delhez, J.; Ougier, J.; de Araujo, F.X.; de Abreu, R.M.; Corbellini, C.
MicroRNA and DNA Methylation Adaptation Mechanism to Endurance Training in Cardiovascular Disease: A Systematic Review. Cardiogenetics 2025, 15, 28.
https://doi.org/10.3390/cardiogenetics15040028
AMA Style
Delhez J, Ougier J, de Araujo FX, de Abreu RM, Corbellini C.
MicroRNA and DNA Methylation Adaptation Mechanism to Endurance Training in Cardiovascular Disease: A Systematic Review. Cardiogenetics. 2025; 15(4):28.
https://doi.org/10.3390/cardiogenetics15040028
Chicago/Turabian Style
Delhez, Jil, Jeanne Ougier, Francisco Xavier de Araujo, Raphael Martins de Abreu, and Camilo Corbellini.
2025. "MicroRNA and DNA Methylation Adaptation Mechanism to Endurance Training in Cardiovascular Disease: A Systematic Review" Cardiogenetics 15, no. 4: 28.
https://doi.org/10.3390/cardiogenetics15040028
APA Style
Delhez, J., Ougier, J., de Araujo, F. X., de Abreu, R. M., & Corbellini, C.
(2025). MicroRNA and DNA Methylation Adaptation Mechanism to Endurance Training in Cardiovascular Disease: A Systematic Review. Cardiogenetics, 15(4), 28.
https://doi.org/10.3390/cardiogenetics15040028
Article Metrics
Article metric data becomes available approximately 24 hours after publication online.
, 
