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Article

Association of GSTT1, GSTM1 and GSTP1 (Ile105Val) mRNA Expression with Cardiometabolic Risk Parameters in Women with Breast Cancer and Comorbidities

1
Facultad de Medicina, Universidad Autónoma del Estado de México, Toluca 50120, Mexico
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Laboratorio de Biología Molecular, Laboratorio Estatal de Salud Pública del Estado de México, Toluca 50130, Mexico
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Unidad Especializada Médica para la Detección de Cáncer de Mama, Instituto de Salud de Estado de México, Toluca 50180, Mexico
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Instituto Jalisciense de Cancerología, Guadalajara 44280, Mexico
*
Author to whom correspondence should be addressed.
Academic Editor: Giuseppe Limongelli
Cardiogenetics 2022, 12(3), 235-245; https://doi.org/10.3390/cardiogenetics12030022
Received: 25 February 2022 / Revised: 21 June 2022 / Accepted: 12 July 2022 / Published: 20 July 2022
(This article belongs to the Section Cardiovascular Genetics in Clinical Practice)
Breast cancer (BC) and cardiometabolic diseases share a multifactorial and modifiable etiology, modulated by complex molecular pathways. Glutathione S-transferase (GST) plays a critical role, providing protection against xenobiotics and regulating levels of enzymes and proteins in the cell. GST variants have a significant impact on susceptibility to diseases whose pathogenesis involves oxidative stress, as is the case in many inflammatory diseases such as BC and cardiometabolic pathologies. However, the expression of these polymorphic variants has not been studied in BC. This study aimed to evaluate the presence of GST mRNA isoforms and their association with clinical and cardiometabolic parameters in women with BC. This was a case-control study, and a total of 57 participants were recruited. Concentrations of glucose and lipids in blood were measured in all the participants. GST variants (GSTT1, GSTM1 and GSTP1 Ile105Val polymorphism) were evaluated in all the participants by real-time PCR analysis. There was a significant association (p < 0.05) between the frequency of GSTP1 and LDL-c in the BC group. However, the control group showed significant associations between blood pressure with GSTT1 and GSTP1 variants with total cholesterol (TC), LDL-c, VLDL-c and triacylglycerols (TG). Therefore, GSTT1 and GSTP1 variants could be emerging biomarkers to discriminate between BC cases related or not to cardiometabolic disease factors. View Full-Text
Keywords: Glutathione S-transferase genotypes; cardiometabolic risk; breast cancer; comorbidities Glutathione S-transferase genotypes; cardiometabolic risk; breast cancer; comorbidities
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MDPI and ACS Style

Becerril Alarcón, Y.; Bastida González, F.; Camacho Beiza, I.R.; Dávila González, E.; Cruz Ramos, J.A.; Benítez Arciniega, A.D.; Valdés Ramos, R.; Soto Piña, A.E. Association of GSTT1, GSTM1 and GSTP1 (Ile105Val) mRNA Expression with Cardiometabolic Risk Parameters in Women with Breast Cancer and Comorbidities. Cardiogenetics 2022, 12, 235-245. https://doi.org/10.3390/cardiogenetics12030022

AMA Style

Becerril Alarcón Y, Bastida González F, Camacho Beiza IR, Dávila González E, Cruz Ramos JA, Benítez Arciniega AD, Valdés Ramos R, Soto Piña AE. Association of GSTT1, GSTM1 and GSTP1 (Ile105Val) mRNA Expression with Cardiometabolic Risk Parameters in Women with Breast Cancer and Comorbidities. Cardiogenetics. 2022; 12(3):235-245. https://doi.org/10.3390/cardiogenetics12030022

Chicago/Turabian Style

Becerril Alarcón, Yizel, Fernando Bastida González, Isidro Roberto Camacho Beiza, Eduardo Dávila González, José Alfonso Cruz Ramos, Alejandra Donají Benítez Arciniega, Roxana Valdés Ramos, and Alexandra Estela Soto Piña. 2022. "Association of GSTT1, GSTM1 and GSTP1 (Ile105Val) mRNA Expression with Cardiometabolic Risk Parameters in Women with Breast Cancer and Comorbidities" Cardiogenetics 12, no. 3: 235-245. https://doi.org/10.3390/cardiogenetics12030022

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