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Volume 10
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10.1080/20016689.2022.2082646
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Journal of Market Access & Health Policy (JMAHP) is published by MDPI from Volume 12 Issue 1 (2024). Previous articles were published by another publisher in Open Access under a CC-BY (or CC-BY-NC-ND) licence, and they are hosted by MDPI on mdpi.com as a courtesy and upon agreement with Taylor & Francis.
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Article

Public Health Impact of COVID-19 in French Ambulatory Patients with at Least One Risk Factor for Severe Disease

by
Aurélie Millier
1,
Romain Supiot
1,*,
Kelly Benyounes
2,
Valérie Machuron
2,
Katell Le Lay
2,
Marine Sivignon
1,
Claire Leboucher
1,
Cécile Blein
1 and
François Raffi
3,4
1
HEOR/HTA, Creativ-Ceutical, Paris, France
2
HEOR, Roche SA France, Paris, France
3
Service de Maladies Infectieuses et Tropicales, CHU de Nantes, Nantes, France
4
CIC UIC 1413 INSERM, CHU de Nantes, Nantes, France
*
Author to whom correspondence should be addressed.
J. Mark. Access Health Policy 2022, 10(1), 2082646; https://doi.org/10.1080/20016689.2022.2082646
Submission received: 24 March 2022 / Revised: 23 May 2022 / Accepted: 23 May 2022 / Published: 10 June 2022

Abstract

Background: Quantification of COVID-19 burden may be useful to support the future allocation of resources. Objective: To evaluate the public health impact of COVID-19 in French ambulatory patients with at least one risk factor for severe disease. Study design: A Markov model was used to estimate life years, costs, number of hospitalisations, number of deaths and long/prolonged COVID forms over a time horizon of 2 years. The hospitalisation probabilities were derived from an early access cohort, and the hospitalisation stay characteristics were derived from the French national hospital discharge database. Several scenario analyses were conducted. Results: The number of hospitalisations reached 256 per 1000 patients over the acute phase (first month of simulation), and 382 per 1000 patients over 2 years. The number of deaths was 37 per 1000 patients, and the number of long/prolonged COVID forms reached 407 per 1000 patients. These translated into a reduction of 0.7 days of life per patient in the first month, with an associated cost of €1578, and a reduction of 27 days of life over the time horizon, with an associated cost of €4280. The highest burden was observed for patients over 80 years old, and those not vaccinated. The scenarios with a less severe situation or new treatments available showed a non-negligible burden reduction. Conclusion: This study allowed us to quantify the considerable burden related to COVID-19 in infected patients, with at least one risk factor for severe form. Strategies with the ability to substantially reduce this burden in France are urgently required.
Keywords: COVID-19; model; simulation; public health impact COVID-19; model; simulation; public health impact

Share and Cite

MDPI and ACS Style

Millier, A.; Supiot, R.; Benyounes, K.; Machuron, V.; Le Lay, K.; Sivignon, M.; Leboucher, C.; Blein, C.; Raffi, F. Public Health Impact of COVID-19 in French Ambulatory Patients with at Least One Risk Factor for Severe Disease. J. Mark. Access Health Policy 2022, 10, 2082646. https://doi.org/10.1080/20016689.2022.2082646

AMA Style

Millier A, Supiot R, Benyounes K, Machuron V, Le Lay K, Sivignon M, Leboucher C, Blein C, Raffi F. Public Health Impact of COVID-19 in French Ambulatory Patients with at Least One Risk Factor for Severe Disease. Journal of Market Access & Health Policy. 2022; 10(1):2082646. https://doi.org/10.1080/20016689.2022.2082646

Chicago/Turabian Style

Millier, Aurélie, Romain Supiot, Kelly Benyounes, Valérie Machuron, Katell Le Lay, Marine Sivignon, Claire Leboucher, Cécile Blein, and François Raffi. 2022. "Public Health Impact of COVID-19 in French Ambulatory Patients with at Least One Risk Factor for Severe Disease" Journal of Market Access & Health Policy 10, no. 1: 2082646. https://doi.org/10.1080/20016689.2022.2082646

APA Style

Millier, A., Supiot, R., Benyounes, K., Machuron, V., Le Lay, K., Sivignon, M., Leboucher, C., Blein, C., & Raffi, F. (2022). Public Health Impact of COVID-19 in French Ambulatory Patients with at Least One Risk Factor for Severe Disease. Journal of Market Access & Health Policy, 10(1), 2082646. https://doi.org/10.1080/20016689.2022.2082646

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