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Pharmaceutics 2017, 9(1), 1;

Chitosan-Based Nano-Embedded Microparticles: Impact of Nanogel Composition on Physicochemical Properties

Section for Pharmaceutical Technology and Engineering, Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
Author to whom correspondence should be addressed.
Academic Editor: Murali Mohan Yallapu
Received: 9 November 2016 / Revised: 14 December 2016 / Accepted: 16 December 2016 / Published: 22 December 2016
(This article belongs to the Special Issue Nanotechnology in Medical Therapeutic Formulations)
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Chitosan-based nanogels have been widely applied as drug delivery vehicles. Spray-drying of said nanogels allows for the preparation of dry powder nano-embedded microparticles. In this work, chitosan-based nanogels composed of chitosan, alginate, and/or sodium tri-penta phosphate were investigated, particularly with respect to the impact of composition on the resulting physicochemical properties. Different compositions were obtained as nanogels with sizes ranging from 203 to 561 nm. The addition of alginate and exclusion of sodium tri-penta phosphate led to an increase in nanogel size. The nanogels were subsequently spray-dried to form nano-embedded microparticles with trehalose or mannitol as matrix excipient. The microparticles of different composition were mostly spherical with a smooth surface and a mass median aerodynamic diameter of 6–10 µm. Superior redispersibility was observed for microparticles containing amorphous trehalose. This study demonstrates the potential of nano-embedded microparticles for stabilization and delivery of nanogel-based delivery systems. View Full-Text
Keywords: Chitosan; nanogels; nano-embedded microparticles; spray-drying; drug delivery Chitosan; nanogels; nano-embedded microparticles; spray-drying; drug delivery

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Islam, P.; Water, J.J.; Bohr, A.; Rantanen, J. Chitosan-Based Nano-Embedded Microparticles: Impact of Nanogel Composition on Physicochemical Properties. Pharmaceutics 2017, 9, 1.

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