Next Article in Journal
Montelukast Disposition: No Indication of Transporter-Mediated Uptake in OATP2B1 and OATP1B1 Expressing HEK293 Cells
Next Article in Special Issue
Microarray Analysis of Differentially-Expressed Genes Encoding CYP450 and Phase II Drug Metabolizing Enzymes in Psoriasis and Melanoma
Previous Article in Journal / Special Issue
Alignment of Short Reads: A Crucial Step for Application of Next-Generation Sequencing Data in Precision Medicine
Article Menu

Export Article

Open AccessReview

Genomic Discoveries and Personalized Medicine in Neurological Diseases

U.S. Food and Drug Administration, Center for Drug Evaluation and Research, 10903 New Hampshire Ave, Silver Spring, MD 20993, USA
U.S. Food and Drug Administration, National Center for Toxicological Research, 3900 NCTR Road, Jefferson, AR 72079, USA
Author to whom correspondence should be addressed.
Academic Editor: Afzal R. Mohammed
Pharmaceutics 2015, 7(4), 542-553;
Received: 23 September 2015 / Revised: 30 November 2015 / Accepted: 2 December 2015 / Published: 7 December 2015
(This article belongs to the Special Issue Personalized Medicine and Pharmacogenomics)
PDF [1279 KB, uploaded 7 December 2015]


In the past decades, we have witnessed dramatic changes in clinical diagnoses and treatments due to the revolutions of genomics and personalized medicine. Undoubtedly we also met many challenges when we use those advanced technologies in drug discovery and development. In this review, we describe when genomic information is applied in personal healthcare in general. We illustrate some case examples of genomic discoveries and promising personalized medicine applications in the area of neurological disease particular. Available data suggest that individual genomics can be applied to better treat patients in the near future. View Full-Text
Keywords: genomics; personalized medicine; neurological disease genomics; personalized medicine; neurological disease

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Share & Cite This Article

MDPI and ACS Style

Zhang, L.; Hong, H. Genomic Discoveries and Personalized Medicine in Neurological Diseases. Pharmaceutics 2015, 7, 542-553.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics



[Return to top]
Pharmaceutics EISSN 1999-4923 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top