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Tacrolimus Pharmacokinetic and Pharmacogenomic Differences between Adults and Pediatric Solid Organ Transplant Recipients

1
Montefiore-Einstein Transplant Center,111 East 210th Street, Bronx, NY 10467, USA
2
School of Pharmacy, State University at Buffalo, 110 Cooke Hall, Buffalo, NY 14215, USA
*
Author to whom correspondence should be addressed.
Pharmaceutics 2010, 2(3), 291-299; https://doi.org/10.3390/pharmaceutics2030291
Received: 5 August 2010 / Revised: 23 August 2010 / Accepted: 30 August 2010 / Published: 9 September 2010
Tacrolimus is a calcineurin inhibitor immunosuppressant that has seen considerable use in both adult and pediatric solid organ transplant recipients. Though there is much pharmacokinetic data available for tacrolimus in the adult population, the literature available for children is limited. Furthermore, very little is known about the pharmacogenomic differences in the two patient groups. Based on what information is currently available, clinically significant differences may exist between the two populations in terms of absorption, distribution, metabolism and elimination. In addition, inherent physiological differences exist in the young child including: less effective plasma binding proteins, altered expression of intestinal P-glycoprotein, and increased expression of phase 1 metabolizing enzymes, therefore one would expect to see clinically significant differences when administering tacrolimus to a child. This paper examines available literature in an attempt to summarize the potential pharmacokinetic and pharmacogenomic variability that exists between the two populations. View Full-Text
Keywords: tacrolimus; FK-506; pharmacokinetics; pharmacogenomics; pediatric transplant tacrolimus; FK-506; pharmacokinetics; pharmacogenomics; pediatric transplant
MDPI and ACS Style

Marfo, K.; Altshuler, J.; Lu, A. Tacrolimus Pharmacokinetic and Pharmacogenomic Differences between Adults and Pediatric Solid Organ Transplant Recipients. Pharmaceutics 2010, 2, 291-299. https://doi.org/10.3390/pharmaceutics2030291

AMA Style

Marfo K, Altshuler J, Lu A. Tacrolimus Pharmacokinetic and Pharmacogenomic Differences between Adults and Pediatric Solid Organ Transplant Recipients. Pharmaceutics. 2010; 2(3):291-299. https://doi.org/10.3390/pharmaceutics2030291

Chicago/Turabian Style

Marfo, Kwaku; Altshuler, Jerry; Lu, Amy. 2010. "Tacrolimus Pharmacokinetic and Pharmacogenomic Differences between Adults and Pediatric Solid Organ Transplant Recipients" Pharmaceutics 2, no. 3: 291-299. https://doi.org/10.3390/pharmaceutics2030291

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